Protein‐Engineered Functional Materials
Protein‐Engineered Functional Materials
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DOI：
10.1002/adhm.201801374
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发表时间：
2019-04
影响因子：
10
通讯作者：
Yao Wang;P. Katyal;J. Montclare
中科院分区：
文献类型：
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作者：
Yao Wang;P. Katyal;J. Montclare
蛋白质是多功能大分子，可以执行多种功能。在过去的三十年中，它们通常被用作生产一系列生物材料的基础材料。由于其灵活性，蛋白质可以单独使用或与其他功能分子结合使用。合成生物学和化学生物学的进步使得新的蛋白质融合以及新功能基团的整合成为可能，从而产生具有新兴特性的生物材料。这篇综述从基于领域的设计以及交联材料的物理和化学方法的角度讨论了蛋白质工程材料，特别强调了水凝胶的创建。还回顾了组织或模板金属离子、带有非规范氨基酸（NCAA）的工程蛋白质及其潜在应用。
Proteins are versatile macromolecules that can perform a variety of functions. In the past three decades, they have been commonly used as building blocks to generate a range of biomaterials. Owing to their flexibility, proteins can either be used alone or in combination with other functional molecules. Advances in synthetic and chemical biology have enabled new protein fusions as well as the integration of new functional groups leading to biomaterials with emergent properties. This review discusses protein‐engineered materials from the perspectives of domain‐based designs as well as physical and chemical approaches for crosslinked materials, with special emphasis on the creation of hydrogels. Engineered proteins that organize or template metal ions, bear noncanonical amino acids (NCAAs), and their potential applications, are also reviewed.