Glycernic control with regular versus lispro insulin sliding scales in hospitalized Type 2 diabetics
Glycernic control with regular versus lispro insulin sliding scales in hospitalized Type 2 diabetics
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DOI：
10.1016/j.jdiacomp.2005.06.009
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发表时间：
2006-05-01
影响因子：
3
通讯作者：
Vigersky, RA
中科院分区：
文献类型：
--
作者：
Alfonso, A;Koops, MK;Vigersky, RA
用途：本研究的目的是在门诊不使用胰岛素的住院2型糖尿病患者中比较常规或赖脯胰岛素滑动量表的血糖控制。研究方法：43例2型糖尿病患者，仅口服药物，住院治疗，随机接受常规或赖脯胰岛素滑动量表。入院时口服糖尿病药物，并在整个住院期间对患者进行随访。结果如下：常规胰岛素组（157.78 +/- 40.16 mg/dl）和赖脯胰岛素组（152.04 +/- 27.71 mg/dl）的平均手指针刺血糖（FSBG）之间无显著差异（P > 0.05）。胰岛素日剂量与对照组相比，（常规，5.83 +/- 5.01单位;赖脯胰岛素，4.27 +/- 3.40单位），住院期间使用的胰岛素总量（常规，11.87 +/- 10.78单位;赖脯胰岛素，12.77 +/- 14.39单位），血糖波动（常规，110.13 ± 25.86 mg/dl;赖脯氨酸，106.77 ± 52.65 mg/dl）或住院时间（常规，2.33 ± 1.23天;赖脯氨酸，2.69 ± 1.59天）。结论：在接受常规或赖脯胰岛素滑动量表治疗的住院2型糖尿病患者中，血糖控制无显著差异。当作为糖尿病的唯一住院治疗时，本研究中使用的两种胰岛素滑动量表均不足以在该患者人群中实现当前推荐的血糖目标。爱思唯尔公司出版
Purpose: The aim of this study was to compare glycemic control with either regular or lispro insulin sliding scales in hospitalized Type 2 diabetics who were not using insulin as outpatients. Methods: Forty-three patients with Type 2 diabetes, who were taking oral agents only, were admitted to a medical inpatient service and randomized to receive either regular or lispro insulin sliding scale. Oral agents for diabetes were held upon admission and patients were followed throughout their hospital stay. Results: There was no significant difference (P > .05) between the average finger-stick blood glucose (FSBG) in the regular insulin group (157.78 +/- 40.16 mg/dl) and the lispro insulin group (152.04 +/- 27.71 mg/dl). No significant difference was found between the daily dose of insulin (regular, 5.83 +/- 5.01 units; lispro, 4.27 +/- 3.40 units), total amount of insulin used during hospitalization (regular, 11.87 +/- 10.78 units; lispro, 12.77 +/- 14.39 units), glucose excursion (regular, 110.13 +/- 25.86 mg/dl; lispro, 106.77 +/- 52.65 mg/dl), or length of hospital stay (regular, 2.33 +/- 1.23 days; lispro, 2.69 +/- 1.59 days). Conclusion: No significant difference in glycemic control was found in hospitalized Type 2 diabetic patients who received either regular or lispro insulin sliding scales. Both insulin sliding scales used in this study are inadequate to achieve current recommended glycemic targets in this patient population, when used as the only inpatient treatment for diabetes. Published by Elsevier Inc.