A contrast-adaptive method for simultaneous whole-brain and lesion segmentation in multiple sclerosis.
A contrast-adaptive method for simultaneous whole-brain and lesion segmentation in multiple sclerosis.
复制标题
多发性硬化症中同时全脑和病变分割的对比适应方法。
DOI:
10.1016/j.neuroimage.2020.117471
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发表时间:
2021-01-15
期刊:
影响因子:
5.7
通讯作者:
Van Leemput K
中科院分区:
文献类型:
--
作者:
Cerri S;Puonti O;Meier DS;Wuerfel J;Mühlau M;Siebner HR;Van Leemput K
Here we present a method for the simultaneous segmentation of white matter lesions and normal-appearing neuroanatomical structures from multi-contrast brain MRI scans of multiple sclerosis patients. The method integrates a novel model for white matter lesions into a previously validated generative model for whole-brain segmentation. By using separate models for the shape of anatomical structures and their appearance in MRI, the algorithm can adapt to data acquired with different scanners and imaging protocols without retraining. We validate the method using four disparate datasets, showing robust performance in white matter lesion segmentation while simultaneously segmenting dozens of other brain structures. We further demonstrate that the contrast-adaptive method can also be safely applied to MRI scans of healthy controls, and replicate previously documented atrophy patterns in deep gray matter structures in MS. The algorithm is publicly available as part of the open-source neuroimaging package FreeSurfer.
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影响因子:
5.7
作者:
Carass A;Roy S;Jog A;Cuzzocreo JL;Magrath E;Gherman A;Button J;Nguyen J;Prados F;Sudre CH;Jorge Cardoso M;Cawley N;Ciccarelli O;Wheeler-Kingshott CAM;Ourselin S;Catanese L;Deshpande H;Maurel P;Commowick O;Barillot C;Tomas-Fernandez X;Warfield SK;Vaidya S;Chunduru A;Muthuganapathy R;Krishnamurthi G;Jesson A;Arbel T;Maier O;Handels H;Iheme LO;Unay D;Jain S;Sima DM;Smeets D;Ghafoorian M;Platel B;Birenbaum A;Greenspan H;Bazin PL;Calabresi PA;Crainiceanu CM;Ellingsen LM;Reich DS;Prince JL;Pham DL
通讯作者:
Pham DL
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3.5
作者:
Blystad, I.;Hakansson, I.;Larsson, E-M.
通讯作者:
Larsson, E-M.
影响因子:
10.6
作者:
Garcia-Lorenzo, Daniel;Prima, Sylvain;Barillot, Christian
通讯作者:
Barillot, Christian
影响因子:
4.8
作者:
Gelineau-Morel R;Tomassini V;Jenkinson M;Johansen-Berg H;Matthews PM;Palace J
通讯作者:
Palace J
影响因子:
5.7
作者:
Fischl, Bruce
通讯作者:
Fischl, Bruce