Immunocytochemical comparison of neurofibrillary tangles in senile dementia of Alzheimer type, progressive supranuclear palsy, and postencephalitic parkinsonism
Immunocytochemical comparison of neurofibrillary tangles in senile dementia of Alzheimer type, progressive supranuclear palsy, and postencephalitic parkinsonism
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阿尔茨海默型老年痴呆、进行性核上性麻痹和脑炎后帕金森病神经原纤维缠结的免疫细胞化学比较
DOI：
10.1002/ana.410130211
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发表时间：
1983
影响因子：
11.2
通讯作者：
R. Terry
中科院分区：
文献类型：
--
作者：
S. Yen;D. Horoupian;R. Terry
在两名进行性核上性麻痹患者的下丘脑、脑桥基底和中脑切片上检测了针对两个循环纯化的人脑微管部分的抗血清，该微管部分特异性结合阿尔茨海默型老年性痴呆的缠结。在这些区域中由15 nm直纤维组成的缠结用抗血清显示阳性免疫标记。标记缠结出现在神经元细胞体中的纤维网，偶尔在短节段的轴突中。从用相同抗血清治疗的特发性帕金森综合征、纹状体黑质变性和橄榄脑桥小脑萎缩患者中获得的相应脑切片未显示过氧化物酶产物。只有在老年受试者和脑炎后帕金森综合征患者中，导水管周围灰质和中缝核偶见与抗血清反应阳性的细胞。脑炎后帕金森综合征患者的黑质中的缠结也被抗血清识别。结果表明，这两个形态上不同的神经元缠结共享其免疫学特性的组件存在于正常大脑的微管部分。
Antiserum raised against a two‐cycle‐purified human brain microtubule fraction that binds specifically to tangles of senile dementia of the Alzheimer type was tested on the subthalamus, basis pontis, and midbrain sections of two patients with progressive supranuclear palsy. Tangles composed of 15 nm straight fibers in these areas showed positive immunolabeling with the antiserum. The labeling tangles appeared as a fibrous meshwork in neuronal cell bodies and occasionally in short segments of axons. Corresponding sections of brains obtained from patients with idiopathic parkinsonism, striatonigral degeneration, and olivopontocerebellar atrophy treated with the same antiserum did not display peroxidase products. Only in the elderly subjects and patients with postencephalitic parkinsonism did the periaqueductal gray and median raphe show occasional cells that reacted positively with the antiserum. Tangles in the substantia nigra of patients with postencephalitic parkinsonism were also recognized by the antiserum. The results suggest that the two morphologically distinct neurofibrillary tangles share their immunological properties with components present in microtubule fractions of normal brain.
神经原纤维缠结的免疫细胞化学研究。
DOI：
--
发表时间：
1981
期刊：
The American journal of pathology
影响因子：
--
作者：
Yen,SH;Gaskin,F;Terry,RD
通讯作者：
Terry,RD