Signaling by olfactory receptor neurons near threshold
Signaling by olfactory receptor neurons near threshold
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DOI：
10.1073/pnas.1004571107
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发表时间：
2010-10-26
影响因子：
11.1
通讯作者：
Yau, King-Wai
中科院分区：
文献类型：
--
作者：
Bhandawat, Vikas;Reisert, Johannes;Yau, King-Wai
感觉系统具有高灵敏度的一个重要因素是感觉受体细胞的灵敏。我们在此报告嗅觉受体神经元（ORN）的信号阈值。我们首先获得了由单个气味结合事件成功触发的青蛙ORN生理电反应大小的最佳估计，其类似于0.034 pA，并且相关的转导结构域仅跨越ORN纤毛长度的一小部分。我们还估计了ORN在响应气味脉冲时激发动作电位的受体电流阈值，该阈值类似于1.2 pA。因此，在短暂的气味脉冲期间，大约需要35个气味结合事件成功触发转导，才能使ORN向大脑发出信号。
An important contributing factor for the high sensitivity of sensory systems is the exquisite sensitivity of the sensory receptor cells. We report here the signaling threshold of the olfactory receptor neuron (ORN). We first obtained a best estimate of the size of the physiological electrical response successfully triggered by a single odorant-binding event on a frog ORN, which was similar to 0.034 pA and had an associated transduction domain spanning only a tiny fraction of the length of an ORN cilium. We also estimated the receptor-current threshold for an ORN to fire action potentials in response to an odorant pulse, which was similar to 1.2 pA. Thus, it takes about 35 odorant-binding events successfully triggering transduction during a brief odorant pulse in order for an ORN to signal to the brain.