STRUCTURE AND MASS OF MITOCHONDRIA IN PROCESS OF COMPENSATORY HYPERFUNCTION AND HYPERTROPHY OF HEART
STRUCTURE AND MASS OF MITOCHONDRIA IN PROCESS OF COMPENSATORY HYPERFUNCTION AND HYPERTROPHY OF HEART
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DOI：
10.1016/0014-4827(64)90313-1
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发表时间：
1964-01-01
影响因子：
3.7
通讯作者：
PSHENNIKOVA, MG
中科院分区：
文献类型：
--
作者：
MEERSON, FZ;ZALETAYEVA, TA;PSHENNIKOVA, MG
在家兔主动脉瓣狭窄致心功能亢进后2、7、45天和8个月的左室心肌电镜切片上，观察了线粒体和肌原纤维所占面积的相关性。在该过程的第一阶段（心脏功能亢进发作后2天和7天），心肌细胞中线粒体质量沿着显著增加，同时部分细胞器被破坏。在第二阶段（心脏功能亢进发作后45天），心肌质量显著增长，随后线粒体的质量和结构正常化。在第三阶段（心脏功能亢进发作后8个月），再次观察到线粒体的破坏伴随着其质量的减少。所示结果与其他器官功能亢进的数据的相关性表明，在分化细胞适应功能水平提高的过程中，产生能量的结构--神经纤维--被增强，并且比直接实现功能的结构更早地经历磨损。
Correlation of areas occupied by mitochondria and myofibrils has been studied in electron microscopic section of myocardium of the left ventricle of rabbits 2,7,45 days and 8 months after the onset of the hyperfunction of the heart produced by aortic stenosis. In the first stage of the process ( 2 and 7 days after the onset of the hyperfunction )f the heart) a significant augmentation of the mitochondrial mass along with a destruction of a part of the organelles arises in myo-cardial cells. In the second stage (45 days after the onset of the hyperfunction of the heart) considerable growth of the myocardial mass is followed by normalization of the mass and structure of the mitochondria. In the third stage (8 months after the onset of the hyperfunction of the heart) the destruction of mitochondria accompanied by a decrease of their mass is again observed. Correlation of the indicated results with data obtained on hyperfunction of other organs suggests that in the process of adaptation of the differentiated cell to the increased level of functioning the energy-producing structures -mitochondria-are augmented and later undergo wear earlier than structures immediately effectuating the function.