Telomere length and urinary 8-hydroxy-2’-deoxyguanosine and essential trace element concentrations in female Japanese university students
Telomere length and urinary 8-hydroxy-2’-deoxyguanosine and essential trace element concentrations in female Japanese university students
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DOI：
10.1080/10934529.2021.1991741
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发表时间：
2021-10
期刊：
影响因子：
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通讯作者：
Yuki Mizuno;S. Konishi;H. Imai;E. Fujimori;N. Kojima;Chiaki Kajiwara;J. Yoshinaga
中科院分区：
文献类型：
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作者：
Yuki Mizuno;S. Konishi;H. Imai;E. Fujimori;N. Kojima;Chiaki Kajiwara;J. Yoshinaga
摘要端粒长度被认为是生物衰老的生物标志物。本研究对73名日本女大学生(年龄19.2±0.7岁)进行了端粒长度与尿中氧化应激标志物8-羟基-2‘-脱氧鸟苷(8-OHdG)和抗氧化性微量元素浓度的相关性研究。用液相色谱-质谱法和电感耦合等离子体质谱分别测定尿中8-OHdG和Se的含量。这项研究使用了先前在同一研究参与者中测量的端粒长度和其他基本微量元素(钼、钴和铬)的尿液浓度。我们使用多元线性回归分析来检验端粒长度与尿8-OHdG和必需微量元素浓度(协变量：尿可替宁浓度、年龄、BMI和饮酒状况)之间的关系。8-OHdG和硒的几何均数(几何标准差)分别为3.4(1.5)和31(1.3)微克/克肌酐。端粒长度与尿8-OHdG浓度无关，但与尿硒浓度呈负相关。总而言之，在这项研究中，年轻女性的端粒长度与尿8-OHdG浓度无关。应该进行纵向研究，以澄清端粒缩短率和氧化应激水平之间的联系。
Abstract Telomere length is thought to be a biomarker of biological aging. This study examined whether telomere length was associated with urinary concentrations of 8-hydroxy-2’-deoxyguanosine (8-OHdG), a biomarker of oxidative stress, and antioxidative trace elements in 73 female Japanese university students (age: 19.2 ± 0.7 years). We quantified 8-OHdG and selenium in urine by liquid chromatography–mass spectrometry and inductively coupled plasma-mass spectrometry, respectively. Telomere length and urinary concentrations of other essential trace elements (molybdenum, cobalt, and chromium) that were previously measured in the same study participants, were used in this study. We used multiple linear regression analysis to examine the associations of telomere length with urinary 8-OHdG and essential trace element concentrations (covariates: urinary cotinine concentration, age, BMI, and drinking status). The geometric means (geometric standard deviation) of 8-OHdG and selenium were 3.4 (1.5) and 31 (1.3) µg/g creatinine, respectively. Telomere length was not associated with urinary 8-OHdG concentration, but was negatively associated with urinary selenium concentration. In conclusion, telomere length was not associated with urinary 8-OHdG concentration in the young women in this study. Longitudinal studies should be conducted to clarify the association between telomere shortening rate and oxidative stress level.