Physical activity and stroke incidence - The Harvard Alumni Health Study
Physical activity and stroke incidence - The Harvard Alumni Health Study
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DOI：
10.1161/01.str.29.10.2049
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发表时间：
1998-10-01
期刊：
影响因子：
8.3
通讯作者：
Paffenbarger, RS
中科院分区：
文献类型：
--
作者：
Lee, IM;Paffenbarger, RS
背景和目的——从生理学角度来看，体力活动似乎有可能降低中风风险；然而，流行病学研究得出的结果好坏参半。此外，很少有研究考察活动的具体种类和强度。本研究的目的是探讨身体活动（包括其各个组成部分（步行、爬楼梯、参与体育和娱乐活动））与中风风险之间的关联。 方法——这是一项前瞻性队列研究，对象为 11130 名基线时没有心血管疾病和癌症的哈佛大学校友（平均年龄 58 岁）。男性在 1977 年的基线调查问卷中报告了他们的步行、爬楼梯以及参与运动或娱乐的情况。1988 年通过另一份调查问卷评估了中风的发生情况。截至 1990 年，我们获取了死者的死亡证明，以确定以前未报告的中风情况（中风总数 = 378）。我们使用 Cox 比例风险回归来估计与体力活动相关的中风发生的相对风险和 95% CI。 结果 - 在调整年龄、吸烟、饮酒和父母过早死亡后，与体力活动相关的中风相对风险
Background and Purpose-PhysiologicaIly, it appears plausible for physical activity to decrease stroke risk; however, epidemiological studies have produced mixed findings. Furthermore, few studies have examined specific kinds and intensities of activities. The purpose of this study was to examine the association between physical activity, including its various components (walking, climbing stairs, participation in sports and recreational activities), and stroke risk.Methods-This was a prospective cohort study of 11 130 Harvard University alumni (mean age, 58 years) without cardiovascular disease and cancer at baseline. Men reported their walking, stair climbing, and participation in sports or recreation on baseline questionnaires in 1977. Stroke occurrence was assessed with another questionnaire in 1988. Death certificates were obtained for decedents through 1990 to determine strokes not previously reported (total strokes = 378). We used Cox proportional hazards regression to estimate the relative risks and 95% CIs for stroke occurrence associated with physical activity.Results-After adjustment for age, smoking, alcohol intake, and early parental death, the relative risks of stroke associated with