Associations of PLA2G7 gene polymorphisms with plasma lipoprotein-associated phospholipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis study
Associations of PLA2G7 gene polymorphisms with plasma lipoprotein-associated phospholipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis study
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DOI：
10.1007/s00439-008-0587-4
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发表时间：
2009-02-01
期刊：
影响因子：
5.3
通讯作者：
Gu, Dongfeng
中科院分区：
文献类型：
--
作者：
Hou, Liping;Chen, Shufeng;Gu, Dongfeng
人PLA 2G 7基因编码脂蛋白相关磷脂酶A（2）（Lp-PLA（2）），这是一种新出现的心血管疾病风险因子。在本研究中，7个单核苷酸多态性（SNPs）的PLA 2G 7基因在827例冠心病（CHD），其中512例心肌梗死（MI）患者，和947名年龄和性别匹配的中国汉族人群的控制基因分型。随机选择416例正常人和689例冠心病患者，其中包括423例心肌梗死患者，测定血浆Lp-PLA（2）活性。冠心病和心肌梗死患者的Lp-PLA（2）活性（分别为233.42 +/- A 57.66和234.27 +/- A 59.51 nmol ml（-1）min（-1））显著高于对照组（211.47 +/- A 58.61 nmol ml（-1）min（-1））。经Logistic回归校正传统危险因素后，Lp-PLA（2）活性每增加1个标准差，冠心病和心肌梗死的比值比分别为1.27（95%CI，1.07-1.50）和1.27（95%CI，1.05-1.54）。单核苷酸多态性分析和单倍型分析均显示V279 F和I198 T多态性与Lp-PLA（2）活性降低显著相关，但与冠心病风险增加无关。单因素和多因素分析，调整传统因素的影响，表明rs 13210554 T等位基因增加MI的风险在这个中国汉族人群。总之，在中国汉族人群中，血浆Lp-PLA（2）活性升高与CHD和MI存在独立相关性。尽管V279 F和I198 T突变显著降低了Lp-PLA的活性，但只有启动子rs 13210554多态性与MI相关。Lp-PLA（2）活性可能影响中国汉族人群冠心病和心肌梗死的危险性。
The human PLA2G7 gene encodes lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an emerging risk factor for cardiovascular diseases. In the present study, seven single nucleotide polymorphisms (SNPs) in the PLA2G7 gene were genotyped in 827 patients with coronary heart disease (CHD), of which 512 were patients with myocardial infarction (MI), and 947 age- and gender-matched controls in a Chinese Han population. Plasma Lp-PLA(2) activity was measured in 416 randomly selected controls and 689 randomly selected CHD patients, including 423 MI patients. Lp-PLA(2) activity in CHD and MI cases was significantly higher (233.42 +/- A 57.66 and 234.27 +/- A 59.51 nmol ml(-1) min(-1), respectively) than in controls (211.47 +/- A 58.61 nmol ml(-1) min(-1)). After adjusting for traditional risk factors by logistic regression, the odds ratios for CHD and MI per 1 standard deviation increment of Lp-PLA(2) activity were 1.27 (95% CI, 1.07-1.50) and 1.27 (95% CI, 1.05-1.54), respectively. Both single SNP analysis and haplotype analysis showed that the V279F and I198T polymorphisms were significantly associated with the reduced Lp-PLA(2) activity, but neither was associated with increased CHD risk. Both univariate and multivariate analyses, adjusting effects of conventional factors, indicated that the rs13210554 T allele increased the risk of MI in this Chinese Han population. In summary, an independent association of increased plasma Lp-PLA(2) activity with CHD and MI existed in this Chinese Han Population. Although V279F and I198T mutations significantly decreased the activity of Lp-PLA(2), only the promoter rs13210554 polymorphism was associated with MI. Lp-PLA(2) activity appears to influence the CHD and MI risk in Chinese Han population.