The Gothenburg Breast Cancer Screening Trial: preliminary results on breast cancer mortality for women aged 39-49.
The Gothenburg Breast Cancer Screening Trial: preliminary results on breast cancer mortality for women aged 39-49.
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哥德堡乳腺癌筛查试验：39-49 岁女性乳腺癌死亡率的初步结果。
DOI：
10.1093/jncimono/1997.22.53
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Johan Säwe
中科院分区：
文献类型：
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作者：
Nils Bjurstam;L. Björneld;Stephen W. Duffy;T. Smith;Erling Cahlin;Olof Erikson;H. Lingaas;Jan E Mattsson;Stellan Persson;Carl;Johan Säwe
我们在瑞典哥德堡市进行了一项邀请筛查乳房X光检查的随机试验，以评估筛查对50岁以下女性乳腺癌死亡率的影响。共有11,724名年龄在39-49岁的女性被随机分配到研究组，每18个月接受一次乳房X光检查；相同年龄范围的14,217名女性被随机分配到对照组，直到研究组的第五次筛查才被邀请进行筛查。在随机化期间和对照组第一次筛查后立即对两组确诊的乳腺癌进行随访，直到1994年12月底。与对照组相比，研究组乳腺癌死亡率显著降低44%(相对风险[RR]=0.56，P=0.042，95%可信区间[CI]：0.32-0.98)。根据对照组第一次筛查发现的癌症切除情况进行保守估计，RR=0.59(P=0.069，95%CI：0.33-1.05)。真正的答案很可能介于这两种估计之间。这些数据表明，乳房X光检查可以降低50岁以下女性的乳腺癌死亡率，特别是如果使用高质量的乳房X光检查，并坚持较短的筛查间隔。
We carried out a randomized trial of invitation to screening mammography in the city of Gothenburg, Sweden, to estimate the effect of screening on breast cancer mortality in women under age 50 years. A total of 11,724 women aged 39-49 were randomized to the study group, which was invited to mammographic screening every 18 months; 14,217 women in the same age range were randomized to a control group, which was not invited to screening until the fifth screen of the study group. Breast cancers diagnosed in both groups between randomization and immediately after the first screen of the control group were followed up for death from breast cancer to the end of December 1994. There was a significant 44% reduction in mortality from breast cancer in the study group compared to the control group (relative risk [RR] = 0.56, P = 0.042, 95% confidence interval [CI]: 0.32-0.98). A conservative estimate based on removal of the cancers detected at the first screen of the control group gave an RR = 0.59 (P = 0.069, 95% CI: 0.33-1.05). The true answer is likely to lie between the two estimates. These data suggest that mammographic screening can reduce breast cancer mortality in women under age 50, particularly if high-quality mammography is used and a short interscreening interval is adhered to.