The role of sex hormones on formalin-induced nociceptive responses
The role of sex hormones on formalin-induced nociceptive responses
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DOI：
10.1016/s0006-8993(02)03661-2
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发表时间：
2002-12-20
期刊：
影响因子：
2.9
通讯作者：
Marchand, S
中科院分区：
文献类型：
--
作者：
Gaumond, I;Arsenault, P;Marchand, S
许多慢性疼痛状况在女性中比男性更常见。这一观察结果表明，性激素对疼痛感知有潜在的作用。在本研究中，我们测量了正常和性腺切除的雄性和雌性大鼠对福尔马林试验的伤害性反应。福尔马林注射的伤害性反应分为四个阶段：急性（阶段1），间期和晚期阶段（阶段II和III）。测试了四组大鼠：（a）雄性（n = 15），（B）雌性（n = 16），（c）卵巢切除雌性（OVX）（n = 15）和（d）去势雄性（CAST）（n = 15）。在第1相、间期和第II相，雌性大鼠的伤害性反应显著高于雄性大鼠（P < 0.01）。在分裂间期，它们的伤害性反应也显著高于OVX雌性（P < 0.05）。CAST组雄性大鼠在Ⅰ、Ⅱ、Ⅲ期的伤害性反应均显著高于雄性大鼠（P <0.01、P < 0.05）。最后，CAST男性和OVX女性的反应几乎是相同的，这表明在福尔马林试验中记录的男性和女性之间的差异与性激素的激活效应有关，而不是组织效应。总之，这些结果允许支持性激素对痛觉调制的作用。有趣的是，男性和女性的性激素似乎在福尔马林试验的不同阶段起着特定的作用，这表明性激素在不同的疼痛条件下起着一些特定的作用。(C)2002 Elsevier Science B.V.保留所有权利。
Many chronic pain conditions are more frequent in women than in men. This observation suggests that there is a potential role of sex hormones on pain perception. In the present study, we measured nociceptive responses to the formalin test in normal and gonadectomized male and female rats. The nociceptive responses to formalin injection were divided in four phases: acute (phase 1), interphase and late phases (phases II and III). Four groups of rats were tested: (a) males (n = 15), (b) females (n = 16), (c) ovariectomized females (OVX) (n = 15) and (d) castrated males (CAST) (n = 15). Females presented significantly more nociceptive responses than males during phase 1, interphase and phase II (P < 0.01). They also presented significantly more nociceptive responses than OVX females during the interphase (P < 0.05). CAST males presented significantly more nociceptive responses during the phases I (P < 0.01), II (P < 0.01) and III (P < 0.05) than the male rats. Finally, the responses of CAST males and OVX females were virtually identical, suggesting that the differences recorded between males and females in the formalin test were related to an activational effect of the sex hormones rather than an organizational effect. In conclusion, these results permit the support of the role of sex hormones on the modulation of pain perception. Interestingly, male and female sex hormones seem to act specifically on the different phases of the formalin test, suggesting some specific roles for sex hormones in different pain conditions. (C) 2002 Elsevier Science B.V. All rights reserved.