Behavioral characterization of a transection of dorsal CA3 subcortical efferents: comparison with scopolamine and physostigmine infusions into dorsal CA3.
Behavioral characterization of a transection of dorsal CA3 subcortical efferents: comparison with scopolamine and physostigmine infusions into dorsal CA3.
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背侧 CA3 皮质下传出神经横切的行为特征：与注射到背侧 CA3 的东莨菪碱和毒扁豆碱进行比较。
DOI：
10.1016/j.nlm.2007.01.006
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发表时间：
2007
影响因子：
2.7
通讯作者：
Kesner,RaymondP
中科院分区：
文献类型：
--
作者：
Hunsaker,MichaelR;Rogers,JasonL;Kesner,RaymondP
从内侧隔和布洛卡斜带向海马体的胆碱能投射长期以来与学习和记忆有关。从CA3到内侧隔膜和Broca斜带的神经元的投影已被解剖表征。本实验旨在评估大鼠CA3背侧皮质下传出神经与布洛卡内侧隔和斜带胆碱能传出神经在空间和非空间（视觉物体）新颖性检测中的相互作用。实验1：在动物背部CA3中注射毒豆碱和东莨菪碱（均为0.4μL, 30μM），并进行空间和非空间（视觉对象）新颖性检测。东莨菪碱注入背侧CA3导致空间和非空间（视觉对象）新颖性检测缺陷。背侧CA3注射毒豆碱增强了空间和非空间（视觉对象）新颖性检测。这些数据支持了乙酰胆碱可能控制海马编码、巩固和检索动态的模型。在实验2中，选择性地切断毛层中背侧CA3传入神经导致空间和非空间（视觉物体）新颖性检测缺陷。这些缺陷与东莨菪碱注入CA3背侧引起的缺陷相似。这些数据表明，CA3背侧与Broca内侧隔/斜带相互作用，并且CA3背侧影响向海马输入的胆碱能以促进编码。
Cholinergic projections from the medial septum and diagonal band of Broca into the hippocampus have long been implicated in learning and memory. Projections from CA3 to neurons in the medial septum and the diagonal band of Broca have been anatomically characterized. The present experiments were designed to evaluate interactions between the dorsal CA3 subcortical efferents and the cholinergic efferents from the medial septum and diagonal band of Broca for spatial and nonspatial (visual object) novelty detection in the rat. In Experiment 1, physostigmine and scopolamine (both 0.4μL at 30μM) were infused into dorsal CA3 and animals were tested on a spatial and nonspatial (visual object) novelty detection paradigm. Scopolamine infusions into dorsal CA3 caused deficits for both spatial and nonspatial (visual object) novelty detection. Physostigmine infusions into dorsal CA3 enhanced both spatial and nonspatial (visual object) novelty detection. These data support models proposing that acetylcholine may control the dynamics for encoding, consolidation, and retrieval in the hippocampus. In Experiment 2, a selective transection of dorsal CA3 efferents in the fimbria resulted in deficits for spatial and nonspatial (visual object) novelty detection. These deficits were similar to the deficits caused by scopolamine infusions into dorsal CA3. These data demonstrate that dorsal CA3 and the medial septum/diagonal band of Broca interact, and that dorsal CA3 influences cholinergic inputs into the hippocampus to facilitate encoding.