Synthesis and antiarrhythmic activity of new [(dialkylamino)alkyl]pyridylacetamides.
Synthesis and antiarrhythmic activity of new [(dialkylamino)alkyl]pyridylacetamides.
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新型[(二烷基氨基)烷基]吡啶基乙酰胺的合成和抗心律失常活性。
DOI：
10.1021/jm00357a026
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发表时间：
1983
影响因子：
7.3
通讯作者：
M. Serre
中科院分区：
文献类型：
--
作者：
C. Bernhart;C. Condamine;H. Demarne;R. Roncucci;J. Gagnol;P. Gautier;M. Serre
报道了新型[(二烷基氨基)烷基]吡啶基乙酰胺的合成。这些化合物显示出有效的抗心律失常活性，如清醒狗心肌梗塞模型所证明的那样。在一系列 22 个同系物中讨论了结构-活性关系，比较了相对的抗心律失常特性和心脏副作用。其中一种化合物 15 已被选为人类临床评估的候选化合物。
The synthesis of new [(dialkylamino) alkyl] pyridylacetamides is reported. These compounds displayed a potent antiarrhythmic activity, as demonstrated on a model of myocardial infarction in the consciousdog. Structure-activity relationships are discussed within a series of 22 homologues, comparing relative antiarrhythmic properties and cardiac side effects. One of these compounds, 15, hasbeen selected as a candidate for clinical evaluation in man.