Panax notoginseng saponins and their applications in nervous system disorders: a narrative review.
Panax notoginseng saponins and their applications in nervous system disorders: a narrative review.
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DOI：
10.21037/atm-20-6909
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发表时间：
2020-11
影响因子：
--
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Qu J;Xu N;Zhang J;Geng X;Zhang R
三七总皂苷(PNS)是从三七(Panax notogiseng(Burk.)其药用传统在中国已有数百年的历史，具有神奇的药用价值。三七总皂苷具有多种生物学功能，如抗炎、抗癌、抗神经毒性、预防糖尿病等。神经系统疾病是源于神经系统的一系列疾病，对患者生活的方方面面都有重大影响。由于全球预期寿命的大幅提高，神经系统疾病的患病率正在逐渐增长。即使这些疾病的发病机制尚不清楚，但它们的主要特征是神经元功能障碍和神经元死亡。因此，必须找到减缓或预防这些疾病发生的措施。目前，中药及其有效成分以其独特的优点在防治这些疾病中得到了广泛的应用，尤其是三七总皂甙。本文主要介绍三七总皂苷及其生物学功能的研究进展，并着重介绍三七总皂苷在阿尔茨海默病(AD)、帕金森病(PD)和卒中等神经系统疾病中的应用。
Panax notoginseng saponins (PNS), also called “sanqi” in Chinese, are the main active ingredients which are extracted from the root of Panax notoginseng (Burk.) F. H. Chen., and they have been traditionally used as a medicine in China for hundreds of years with magical medicinal value. PNS have varied biological functions, such as anti-inflammatory effects, anti-cancer effects, anti-neurotoxicity, and the prevention of diabetes. Nervous system disorders, a spectrum of diseases originating from the nervous system, have a significant impact on all aspects of patients’ lives. Due to the dramatic gains in global life expectancy, the prevalence of nervous system disorders is growing gradually. Even if the mechanism of these diseases is still not clear, they are mainly characterized by neuronal dysfunction and neuronal death. Consequently, it is essential to find measures to slow down or prevent the onset of these diseases. At present, traditional Chinese medicines, as well as their active components, have gained widespread popularity in preventing and treating these diseases because of their merits, especially PNS. In this review, we predominantly address the recent advances in PNS researches and their biological functions, and highlight their applications in nervous system disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke.