Gene for parathyroid hormone-like peptide is on rat chromosome 2.
Gene for parathyroid hormone-like peptide is on rat chromosome 2.
复制标题
甲状旁腺激素样肽的基因位于大鼠 2 号染色体上。
DOI：
10.1016/s0006-291x(88)80285-7
复制
发表时间：
1988
影响因子：
3.1
通讯作者：
Goltzman,D
中科院分区：
文献类型：
--
作者：
Hendy,GN;Sakaguchi,AY;Yasuda,T;Weber,DK;Wang,LM;Yoshida,MC;Banville,D;Goltzman,D
甲状旁腺激素样肽(PLP)被认为是人类和啮齿动物恶性肿瘤中高钙血症的媒介。用大鼠PLP基因作为杂交探针，对从一组大鼠-小鼠体细胞杂交中分离的DNA进行Southern杂交分析。PLP的单拷贝基因被分配到大鼠的第二染色体上，而大鼠甲状旁腺激素(PTH)基因被分配到大鼠的第一染色体上。因此，尽管PLP和PTH在氨基末端有显著的同源性，但编码这些肽的基因在大鼠和人类中都有不同的染色体定位。
Parathyroid hormone-like peptide (PLP) is thought to be a mediator of hypercalcemia in both human and rodent malignancies. A rat PLP cDNA was used as a hybridization probe in Southern blot analysis of DNAs isolated from a panel of rat-mouse somatic cell hybrids. The single-copy gene for PLP was assigned to rat chromosome 2, whereas the rat parathyroid hormone (PTH) gene has previously been assigned to rat chromosome 1. Consequently, despite significant amino-terminal homology between PLP and PTH the genes encoding these peptides in the rat as well as human species have discrete chromosomal localizations.