IL-8 Expression in Granulocytic Epithelial Lesions of Idiopathic Duct-centric Pancreatitis (Type 2 Autoimmune Pancreatitis)
IL-8 Expression in Granulocytic Epithelial Lesions of Idiopathic Duct-centric Pancreatitis (Type 2 Autoimmune Pancreatitis)
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DOI：
10.1097/pas.0000000000000891
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发表时间：
2017-08-01
影响因子：
5.6
通讯作者：
Zen, Yoh
中科院分区：
文献类型：
--
作者：
Ku, Yuna;Hong, Seung-Mo;Zen, Yoh
2型自身免疫性胰腺炎(2型AIP)是孤立发生的，有时与溃疡性结肠炎有关。它的诊断需要粒细胞上皮损伤(凝胶)的组织学确认，目前还没有可用的诊断生物标记物。本研究旨在阐明细胞因子在该疾病中的组织表达及其诊断价值。多细胞因子定量聚合酶链式反应中，IL-8在2型AIP中的表达水平明显高于1型AIP(P<0.05)。
Type 2 autoimmune pancreatitis (type 2 AIP) develops in isolation or sometimes in association with ulcerative colitis. Its diagnosis requires the histologic confirmation of granulocytic epithelial lesions (GELs) with no diagnostic biomarker currently available. This study aimed to elucidate the tissue expression of cytokines and their diagnostic value in this condition. In quantitative polymerase chain reaction for multiple cytokines using tissue-derived mRNA, the expression level of interleukin (IL)-8 was markedly higher in type 2 AIP than in type 1 AIP (P