SITE-SPECIFIC ENHANCEMENT AND SUPPRESSION OF DESYNCHRONIZED SLEEP SIGNS FOLLOWING CHOLINERGIC STIMULATION OF 3 BRAIN-STEM REGIONS
SITE-SPECIFIC ENHANCEMENT AND SUPPRESSION OF DESYNCHRONIZED SLEEP SIGNS FOLLOWING CHOLINERGIC STIMULATION OF 3 BRAIN-STEM REGIONS
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DOI：
10.1016/0006-8993(84)90354-8
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
HOBSON, JA
中科院分区：
文献类型：
--
作者：
BAGHDOYAN, HA;RODRIGOANGULO, ML;HOBSON, JA
研究了脑桥、中脑和延髓网状结构（RF）内微量注射卡巴胆碱的行为学效应。电图去极化（D）睡眠体征和D睡眠样行为的增强是脑桥特有的;在中脑和延髓RF的胆碱能刺激后，这些参数被对比抑制。当卡巴胆碱注射到所有3个脑干区域时，中脑和延髓的多导睡眠觉醒（W）增加，其特征是刻板的运动活动，而慢波（S）睡眠减少或消除。此外，作为脑桥内卡巴胆碱给药部位的函数，观察到卡巴胆碱诱导的D睡眠和生理D睡眠状态之间的一些定性电图差异。这些结果与脑桥RF参与胆碱能启动和/或维持D睡眠以及中脑RF通过胆碱能网状细胞介导唤醒的假设一致。这一假设，即髓RF中起着重要作用的S睡眠和D睡眠的张力缺乏的产生是不支持这些数据，但这些建议的作用的非胆碱能机制仍有待研究。
The behavioral effects of carbachol microinjection into the pontine, midbrain and medullary reticular formation (RF) have been studied. Enhancement of electrographic desynchronized (D) sleep signs and D sleep-like behavior was specific to the pons; there parameters were contrastingly suppressed following cholinergic stimulation of the midbrain and medullary RF. Polygraphically defined wakefulness (W) was increased from the midbrain and medulla and was characterized by stereotyped motor activity, whereas slow wave (S) spleep was reduced or eliminated when carbachol was administered into all 3 brainstem regions. In addition, as a function of the site of carbachol administration within the pons, some qualitative electrographic differences between carbachol-induced D sleep and the physiological D sleep state were observed. These results are consistent with the hypotheses that the pontine RF is involved in the cholinergic initiation and/or maintenance of D sleep and that the midbrain RF mediates arousal via cholinoceptive reticular cells. The hypothesis that the medullary RF plays a major role in the generation of S sleep and the atonia of D sleep is not supported by these data, but non-cholinergic mechanisms of these proposed roles remain to be investigated.