MRI study of subconjunctival and intravitreal injections.
MRI study of subconjunctival and intravitreal injections.
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DOI：
10.1002/jps.23127
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发表时间：
2012-07
影响因子：
3.8
通讯作者：
Lee, Jing-Huei
中科院分区：
文献类型：
--
作者：
Li, S. Kevin;Hao, Jinsong;Liu, Hongshan;Lee, Jing-Huei
关键词：
以往的磁共振成像（MRI）研究研究了药物在眼内的渗透途径和屏障，为药物经巩膜和眼内给药的机制提供了见解。本研究的目的是调查结膜下和玻璃体内注射造影剂浓度高于以往研究的情况后的眼部穿透和清除。假设这种高浓度的方法可以使造影剂在眼睛内的可视化，这在以前是无法实现的。在家兔结膜下和玻璃体内注射造影剂Magnevist（一种模型亲水性探针），并通过MRI检查注射后探针的分布和清除情况。在体内结膜下注射造影剂后，观察到有明显的造影剂进入前房，但没有进入玻璃体。发现亲水探针从结膜下储存库到眼后眼周脂肪附近区域的清除途径。体内玻璃体内注射造影剂后，在清除过程中观察到前房、视神经和眼周组织的造影剂。MRI继续为亲水分子在眼部传递中的运输障碍和清除途径提供见解。
Previous magnetic resonance imaging (MRI) studies to investigate the routes of penetration and barriers in ocular delivery have provided insights into the mechanisms of transscleral and intraocular drug delivery. The objective of the present study was to investigate ocular penetration and clearance after subconjunctival and intravitreal injections using a contrast agent at concentrations higher than those in the previous studies. This high concentration approach was hypothesized to allow the visualization of the contrast agent in the eye that could not be achieved previously. Subconjunctival and intravitreal injections of contrast agent Magnevist, a model hydrophililc probe, were performed in rabbits, and the distribution and clearance of the probe after the injections were examined by MRI. After subconjunctival injection in vivo, significant contrast agent penetration into the anterior chamber was observed but not into the vitreous. A clearance pathway of the hydrophilic probe from the subconjunctival depot to the regions near the periocular fat behind the eye was found. After intravitreal injection in vivo, the contrast agent was observed in the anterior chamber, optic nerve, and tissues surrounding the eye during clearance. MRI continues to provide insights into the transport barriers and clearance pathways of hydrophilic molecules in ocular delivery.
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DOI：
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发表时间：
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