MiR-486-3p targeting ECM1 represses cell proliferation and metastasis in cervical cancer
MiR-486-3p targeting ECM1 represses cell proliferation and metastasis in cervical cancer
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DOI：
10.1016/j.biopha.2016.02.019
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发表时间：
2016-05-01
影响因子：
7.5
通讯作者：
Chen, Feng
中科院分区：
文献类型：
--
作者：
Ye, Haiqiong;Yu, Xiaolan;Chen, Feng
MicroRNAs （miRNAs）调节基因表达并参与宫颈癌。但其分子机制尚不清楚。这里，我们进行了宫颈癌的miRNA谱分析，发现miR-486-3p在宫颈癌患者标本中降低。此外，我们的临床数据显示miR-486-3p的降低与宫颈癌患者的转移有关。预测并证实ECM1是miR-486-3p的靶基因。过表达miR-486-3p通过靶向ECM1抑制细胞生长和转移。总之，这些发现表明miR-486-3p是一种肿瘤抑制miRNA，诱导miR-486-3p是抑制宫颈癌进展的潜在策略。(C) 2016年由Elsevier Masson SAS出版。
MicroRNAs (miRNAs) regulate gene expression and are involved in cervical cancer. But the molecular mechanism is still unclear. Here, miRNA profile of cervical cancer was performed and demonstrated that miR-486-3p decreased in specimens of cervical cancer patients. In addition, our clinical data show that decreased miR-486-3p was associated with metastasis in cervical cancer patients. ECM1 was predicted and velified as a target gene of miR-486-3p. Overexpression of miR-486-3p inhibited cell growth and metastasis by targeting ECM1. In a conclusion, these findings suggest that miR-486-3p is a tumor suppressor miRNA and induction of miR-486-3p is a potential strategy to inhibit cervical cancer progression. (C) 2016 Published by Elsevier Masson SAS.