Basal forebrain stimulation modifies auditory cortex responsiveness by an action at muscarinic receptors
Basal forebrain stimulation modifies auditory cortex responsiveness by an action at muscarinic receptors
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基底前脑刺激通过毒蕈碱受体的作用改变听觉皮层的反应性
DOI：
10.1016/0006-8993(91)90301-b
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发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
J. Ashe
中科院分区：
文献类型：
--
作者：
R. Metherate;J. Ashe
我们假设听觉皮层可塑性涉及基底前脑（BF）胆碱能神经元对丘脑皮质传递的修饰，并且这种作用可能涉及毒蕈碱受体。在这个假设的第一次测试中，我们报告说，根据刺激的强度，BF 刺激可以抑制或促进丘脑刺激引起的听觉皮层反应。 BF 介导的促进作用被阿托品拮抗，涉及毒蕈碱受体。这些数据表明 BF 胆碱能神经元通过调节丘脑皮质传递来功能性地改变听觉皮层。
We have hypothesized that auditory cortex plasticity involves modification of thalamocortical transmission by basal forebrain (BF) cholinergic neurons, and that this action may involve muscarinic receptors. In a first test of this hypothesis, we report that BF stimulation can suppress or facilitate, depending on the intensity of stimulation, auditory cortical responses elicited by thalamic stimulation. BF-mediated facilitation is antagonized by atropine, implicating muscarinic receptors. These data suggest that BF cholinergic neurons functionally modify auditory cortex by regulating thalamocortical transmission.