When is a hydrophobic gate not a hydrophobic gate?
When is a hydrophobic gate not a hydrophobic gate?
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DOI：
10.1085/jgp.202213210
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发表时间：
2022-11-07
影响因子：
3.8
通讯作者：
Tucker, Stephen J.
中科院分区：
文献类型：
--
作者：
Seiferth, David;Biggin, Philip C.;Tucker, Stephen J.
离子通过通道的流量通常由导致其孔的空间阻塞的变化来调节。然而，离子渗透也可以通过形成由排列在孔中的疏水残基产生的去溶剂化屏障来防止。作为相对较小的结构变化的结果，通道中的受限疏水区域可以经历湿态和干态之间的转变以门控孔闭合而不对渗透路径进行物理收缩。这个概念被称为疏水门控，并且已经证明了这个过程的许多示例。然而，这个词现在也被用于更广泛的背景下，往往偏离其原来的含义。在这个观点中，我们探讨了疏水门的正式定义，讨论了这个过程的例子相比，其他门控机制，简单地利用疏水残基和/或脂质的空间位阻的孔，并描述了识别疏水门的最佳实践。
The flux of ions through a channel is most commonly regulated by changes that result in steric occlusion of its pore. However, ion permeation can also be prevented by formation of a desolvation barrier created by hydrophobic residues that line the pore. As a result of relatively minor structural changes, confined hydrophobic regions in channels may undergo transitions between wet and dry states to gate the pore closed without physical constriction of the permeation pathway. This concept is referred to as hydrophobic gating, and many examples of this process have been demonstrated. However, the term is also now being used in a much broader context that often deviates from its original meaning. In this Viewpoint, we explore the formal definition of a hydrophobic gate, discuss examples of this process compared with other gating mechanisms that simply exploit hydrophobic residues and/or lipids in steric closure of the pore, and describe the best practice for identification of a hydrophobic gate.
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影响因子：
16.6
作者：
Aryal, Prafulla;Abd-Wahab, Firdaus;Bucci, Giovanna;Sansom, Mark S. P.;Tucker, Stephen J.
通讯作者：
Tucker, Stephen J.
影响因子：
16.6
作者：
Jin R;He S;Black KA;Clarke OB;Wu D;Bolla JR;Johnson P;Periasamy A;Wardak A;Czabotar P;Colman PM;Robinson CV;Laver D;Smith BJ;Gulbis JM
通讯作者：
Gulbis JM
影响因子：
64.8
作者：
Jumper J;Evans R;Pritzel A;Green T;Figurnov M;Ronneberger O;Tunyasuvunakool K;Bates R;Žídek A;Potapenko A;Bridgland A;Meyer C;Kohl SAA;Ballard AJ;Cowie A;Romera-Paredes B;Nikolov S;Jain R;Adler J;Back T;Petersen S;Reiman D;Clancy E;Zielinski M;Steinegger M;Pacholska M;Berghammer T;Bodenstein S;Silver D;Vinyals O;Senior AW;Kavukcuoglu K;Kohli P;Hassabis D
通讯作者：
Hassabis D
影响因子：
64.8
作者：
Chen I;Pant S;Wu Q;Cater RJ;Sobti M;Vandenberg RJ;Stewart AG;Tajkhorshid E;Font J;Ryan RM
通讯作者：
Ryan RM
影响因子：
7.7
作者：
Drozdzyk, Katarzyna;Sawicka, Marta;Dutzler, Raimund
通讯作者：
Dutzler, Raimund