CYTOCHROME-P450 AND THE ARACHIDONATE CASCADE
CYTOCHROME-P450 AND THE ARACHIDONATE CASCADE
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DOI：
10.1096/fasebj.6.2.1537463
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发表时间：
1992-01-06
期刊：
影响因子：
4.8
通讯作者：
ESTABROOK, RW
中科院分区：
文献类型：
--
作者：
CAPDEVILA, JH;FALCK, JR;ESTABROOK, RW
花生四烯酸和花生四烯酸级联的许多产物可作为细胞色素 P450 介导的代谢的底物，通过烯丙基氧化、欧米茄羟基化、环氧化以及过氧化物重排。定义这些代谢物的生理重要性是一个备受研究兴趣的领域。细胞色素 P450 催化的反应在增加花生四烯酸代谢级联的结构和功能多样性方面发挥着重要作用。
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.