No change in the distribution of types and antibiotic resistance in clinical Staphylococcus aureus isolates from orthopaedic patients during a period of 12 years
No change in the distribution of types and antibiotic resistance in clinical Staphylococcus aureus isolates from orthopaedic patients during a period of 12 years
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DOI：
10.1007/s10096-015-2420-z
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发表时间：
2015-09-01
影响因子：
4.5
通讯作者：
Skramm, I.
中科院分区：
文献类型：
--
作者：
Aamot, H. V.;Stavem, K.;Skramm, I.
金黄色葡萄球菌(S.金黄色葡萄球菌）是骨和关节感染的最常见原因。然而，关于S的分布信息有限。金黄色葡萄球菌的基因型和表型导致骨科感染。本研究的目的是确定骨科患者中引起感染的主要类型，调查这些类型的特征是否随时间发生变化，并检查不同类型是否更常与手术部位感染（SSI）相关，而不是与原发性感染（非SSI）相关。所有临床S。从2000年至2011年在挪威阿克尔舒斯大学医院从骨科患者中收集的金黄色葡萄球菌分离株的特征为S.金黄色葡萄球菌蛋白A（spa）分型和抗生素耐药性测试。共548例骨科S.金黄色葡萄球菌感染，其中326例（59%）发生SSI，222例（41%）发生非SSI。中位年龄为62岁[范围2-97岁]，54%为男性。在242个独特的温泉类型中，t084最常见（7%）。75%的分离株对青霉素耐药，而对其他抗生素的耐药率<5%。3株（0.5%）对甲氧西林耐药。随着时间的推移，基因型和表型的分布没有显著差异，SSI和非SSI之间的类型也没有差异。在这一大集合的S。金黄色葡萄球菌（S.不管来源如何，金黄色葡萄球菌感染是异质性的，主要对青霉素耐药，随时间稳定，并且由与先前在携带者和其它患者群体中发现的相似类型组成。
Staphylococcus aureus (S. aureus) is the most common cause of bone and joint infections. However, limited information is available on the distribution of S. aureus geno- and phenotypes causing orthopaedic infections. The aim of this study was to identify the dominating types causing infections in orthopaedic patients, investigate if the characteristics of these types changed over time and examine if different types were more often associated with surgical site infection (SSI) than primary infection (non-SSI). All clinical S. aureus isolates collected from orthopaedic patients from 2000 through 2011 at Akershus University Hospital, Norway, were characterised by S. aureus protein A (spa) typing and tested for antibiotic resistance. A total of 548 patients with orthopaedic S. aureus infections were included, of which 326 (59 %) had SSI and 222 (41 %) had non-SSI. The median age was 62 years [range 2-97 years] and 54 % were male. Among the 242 unique spa types, t084 was the most common (7 %). Penicillin resistance was identified in 75 % of the isolates, whereas the resistances to the other antibiotics tested were < 5 %. Three isolates (0.5 %) were resistant to methicillin. There was no significant difference in the distribution of geno- and phenotypes over time and there was no difference in types between SSI and non-SSI. In this large collection of S. aureus from orthopaedic patients, the S. aureus infections, regardless of origin, were heterogeneous, mainly resistant to penicillin, stable over time and consisted of similar types as previously found in both carrier and other patient populations.