The unique role of apolipoprotein A-I in HDL remodeling and metabolism.
The unique role of apolipoprotein A-I in HDL remodeling and metabolism.
复制标题
载脂蛋白 A-I 在 HDL 重塑和代谢中的独特作用。
DOI：
10.1097/01.mol.0000226110.66942.e8
复制
发表时间：
2006
影响因子：
4.4
通讯作者：
Ehnholm,Christian
中科院分区：
文献类型：
--
作者：
Pownall,HenryJ;Ehnholm,Christian
The compositions, structures, and properties of HDL particles are important determinants of the mechanisms by which these antiatherogenic lipoproteins are metabolized. Although the plasma lipid transfer proteins and lipid-modifying enzymes are important determinants of HDL processing, the distinctive structures and properties of apoA-I and apoA-II, the two major HDL proteins, determine in different ways the thermodynamic stability of HDL–the former through its greater plasticity and the latter by its higher lipophilicity. These distinctions have been revealed by physico-chemical studies of HDL stability in the context of numerous studies of enzyme and lipid transfer activities and of the interaction of HDL with its hepatic scavenger receptor.
