Domain-specific and domain-general learning factors are expressed in genetically heterogeneous CD-1 mice
Domain-specific and domain-general learning factors are expressed in genetically heterogeneous CD-1 mice
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DOI：
10.1016/j.intell.2007.12.001
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发表时间：
2008-11-01
期刊：
影响因子：
3
通讯作者：
Matzel, Louis D.
中科院分区：
文献类型：
--
作者：
Kolata, Stefan;Light, Kenneth;Matzel, Louis D.
已经确定的是，特定领域（如空间）和一般领域（一般智力）因素都会影响人类的认知。然而，在使用实验动物的研究中很少尝试分离这些过程。在此之前，我们已经发现，近亲繁殖的老鼠在广泛的团队任务中的表现相互关联，这样一个单一的因素可以解释动物之间30-44%的差异。这种一般的学习因素在某种程度上和人类的一般智力在质量和数量上是相似的。然而，由于我们之前分析的样本量有限，尚未探索小鼠认知的完整结构。在这里，我们报告了对241只CD-I小鼠在五个主要学习任务中测试的综合分析，以及在两个额外学习任务中测试的小鼠子集。七个学习任务中至少有两个（可能是三个）明确要求空间和/或海马体依赖的处理能力。与先前的研究结果一致，我们报告了影响小鼠学习的一个强大的一般因素，该因素占任务差异的38%。此外，研究人员还发现了一个特定领域的因素，可以解释海马和/或空间处理共同依赖的任务子集的表现。这些结果为遗传异质性小鼠的学习/认知因素提供了进一步的证据。此外（与人类的认知表现相似），这些结果表明，这种基因异质物种的认知过程存在层次结构，(C) 2008 Elsevier Inc。版权所有。
It has been established that both domain-specific (e.g. spatial) as well as domain-general (general intelligence) factors influence human cognition. However, the separation of these processes has rarely been attempted in studies using laboratory animals. Previously, we have found that the performances of outbred mice across a wide range of teaming tasks correlate ill Such a way that a single factor can explain 30-44% of the variance between animals. This general learning factor is in some ways qualitatively and quantitatively analogous to general intelligence in humans. The complete structure of cognition in mice, however, has not been explored due to the limited sample sizes of our previous analyses. Here we report a combined analysis from 241 CD-I mice tested in five primary learning tasks, and a subset of mice tested in two additional learning tasks. At least two (possibly three) of tire seven learning tasks placed explicit demands on spatial and/or hippocampus-dependent processing abilities. Consistent with previous findings, we report a robust general factor influencing learning in mice that accounted for 38% of the variance across tasks. Ill addition, a domain-specific factor was found to account for performance on that subset of tasks that shared a dependence oil hippocampal and/or spatial processing. These results provide further evidence for it general learning/cognitive factor in genetically heterogeneous mice. Furthermore (and similar to human cognitive performance), these results suggest a hierarchical structure to cognitive processes in this genetically heterogeneous species, (C) 2008 Elsevier Inc. All rights reserved.