New developments implicating IL-21 in autoimmune disease.
New developments implicating IL-21 in autoimmune disease.
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DOI：
10.1016/j.jaut.2021.102689
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发表时间：
2021-08
影响因子：
12.8
通讯作者：
Olsen NJ
中科院分区：
文献类型：
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作者：
Ren HM;Lukacher AE;Rahman ZSM;Olsen NJ
Elevated interleukin (IL)-21 is a common finding in the tissues and/or sera of patients with autoimmune disease. CD4 T cells are the primary producers of IL-21; often the IL-21 producing CD4 T cells will express molecules associated with follicular helper cells (TFH). Recent work has shown that the CD4 T cell-derived IL-21 is able to promote effector functions and memory differentiation of CD8 T cells in chronic infections and cancer. Autoimmunity has similarities to chronic infections and cancer. However, CD4 T cell-derived IL-21:IL21R signaling in CD8 T cells has not been fully appreciated in the context of autoimmunity. In this review, we assess the current knowledge regarding CD4 T cell-derived IL-21 and IL21R signaling within CD8 T cells and evaluate what implications it has within several autoimmune diseases including systemic lupus erythematous, rheumatoid arthritis, juvenile idiopathic arthritis, type 1 diabetes mellitus, psoriasis, Sjögren’s syndrome, vitiligo, antiphospholipid syndrome, pemphigus, and giant cell arteritis.
DOI：
10.4049/jimmunol.0804215
发表时间：
2009-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Vuyyuru R;Mohan C;Manser T;Rahman ZS
通讯作者：
Rahman ZS