Regulation of senescence in cancer and aging.
Regulation of senescence in cancer and aging.
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DOI：
10.4061/2011/963172
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发表时间：
2011-03-08
影响因子：
4.7
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Kong Y;Cui H;Ramkumar C;Zhang H
衰老被认为是细胞对应激的生理反应，包括端粒功能障碍、异常致癌激活、DNA损伤和氧化应激。这种应激反应对生物体具有拮抗性多效性效应：作为肿瘤抑制剂是有益的，但通过促进衰老而有害。衰老作为一种有效的肿瘤抑制机制的出现，最近的研究表明，衰老可以防止处于肿瘤转化风险的细胞增殖。因此，衰老的诱导被认为是癌症的潜在治疗。大量证据还表明，衰老在衰老中起着重要作用，特别是在干细胞衰老中。在本文中，我们将讨论衰老的分子调控及其在癌症和衰老中的作用。衰老在癌症治疗中的潜在效用也将被讨论。
Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed.