Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration.
Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration.
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DOI：
10.1016/j.ophtha.2008.05.017
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发表时间：
2008-08-01
期刊：
影响因子：
13.7
通讯作者：
Schmidt-Erfurth, Ursula
中科院分区：
文献类型：
--
作者：
Ahlers, Christian;Golbaz, Isabelle;Schmidt-Erfurth, Ursula
目得：分析雷珠单抗治疗对年龄相关性黄斑变性视网膜和视网膜下室的影响，并比较室特异性效应对视觉功能的时间过程。设计：前瞻性非比较性病例系列。参与者：14例3个主要室由于新生血管性年龄相关性黄斑变性的变化。方法：标准治疗与3个月剂量的玻璃体内雷珠单抗进行。使用标准化方案在基线和第1、4和12周检查眼睛。手动分割应用于所有128个B扫描包含在一个黄斑光栅扫描（MRS）。主要结果measurements：不同的视网膜和视网膜下compartments.Results：形态和时间过程中的高清晰度的光学相干断层扫描和手动分割允许精确识别的体积内的个别舱室。所有形态学参数对治疗均呈阳性反应，但表现出特定的时间进程。视网膜下液被确定为最相关的因素，视功能，而视网膜和色素下上皮细胞体积的变化并不相关的时间过程中的功能rehabilitation.CONCLUSION：分析MRS确定了一个特征性的影响治疗视网膜和视网膜下形态。
PURPOSE: To analyze the effect of ranibizumab therapy on retinal and subretinal compartments in age-related macular degeneration and to compare the time course of compartment specific effects to visual function.DESIGN: Prospective noncomparative case series.PARTICIPANTS: Fourteen patients with changes in 3 major compartments owing to neovascular age-related macular degeneration.METHODS: Standard treatment with 3 monthly doses of intravitreal ranibizumab was performed. Eyes were examined at baseline and weeks 1, 4, and 12 using a standardized protocol. Manual segmentation was applied to all 128 B-scans contained in a macular raster scan (MRS).MAIN OUTCOME MEASURES: Morphology and time course of different retinal and subretinal compartments.RESULTS: High-definition optical coherence tomography and manual segmentation allowed for precise identification of volumes within individual compartments. All morphologic parameters responded positively to therapy, but demonstrated a specific time course. Subretinal fluid was identified as the most relevant factor for visual function, whereas changes in retinal and subpigment epithelial volumes did not correlate with the time course of functional rehabilitation.CONCLUSION: Analysis of MRS identified a characteristic impact of therapy on retinal and subretinal morphology.