Increased prefrontal hemodynamic change after atomoxetine administration in pediatric attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy
Increased prefrontal hemodynamic change after atomoxetine administration in pediatric attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy
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DOI：
10.1111/pcn.12251
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发表时间：
2015-03-01
影响因子：
11.9
通讯作者：
Kishimoto, Toshifumi
中科院分区：
文献类型：
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作者：
Ota, Toyosaku;Iida, Junzo;Kishimoto, Toshifumi
2009年4月，托莫西汀在日本获批用于治疗儿童注意力缺陷/多动障碍（ADHD），是一种非兴奋剂，被认为通过抑制去甲肾上腺素再摄取在突触前发挥作用。近红外光谱是一种非侵入性的光学工具，可用于研究大脑皮层中的氧合和血流动力学变化。本研究探讨了临床剂量的托莫西汀对ADHD儿童前额叶血流动力学活动的变化的影响，通过近红外光谱使用Stroop色词Task.MethodsTen ADHD儿童参加了本研究。我们使用24通道近红外光谱法测量了未使用过药物的参与者和接受托莫西汀治疗8周的参与者额叶中氧合血红蛋白的相对浓度。在Stroop色词任务期间，每0.1s进行一次测量。我们使用的ADHD评定量表-IV-日本版（家庭版），以评估ADHD symptoms.ResultsWe发现一个显着减少ADHD评定量表-IV-日本版分数，从30.7至22.6（P=0.003）。在Stroop色字任务，我们发现显着更高水平的氧合血红蛋白的变化，在前额叶皮质的参与者在托莫西汀条件相比，那些在药物-幼稚condition.ConclusionsThis增加氧合血红蛋白的变化可能表明加强前额叶血流动力学反应诱导托莫西汀。近红外光谱是测量托莫西汀在ADHD儿童中药理作用的灵敏工具。
AimAtomoxetine, approved in Japan for the treatment of pediatric attention-deficit/hyperactivity disorder (ADHD) in April 2009, is a nonstimulant that is thought to act presynaptically via the inhibition of norepinephrine reuptake. Near-infrared spectroscopy is a non-invasive optical tool that can be used to study oxygenation and hemodynamic changes in the cerebral cortex. The present study examined the effects of a clinical dose of atomoxetine on changes in prefrontal hemodynamic activity in children with ADHD, as measured by near-infrared spectroscopy using the Stroop Color-Word Task.MethodsTen children with ADHD participated in the present study. We used 24-channel near-infrared spectroscopy to measure the relative concentrations of oxyhemoglobin in the frontal lobes of participants in the drug-naive condition and those who had received atomoxetine for 8 weeks. Measurements were conducted every 0.1s during the Stroop Color-Word Task. We used the ADHD Rating Scale-IV-Japanese version (Home Version) to evaluate ADHD symptoms.ResultsWe found a significant decrease in ADHD Rating Scale-IV-Japanese version scores, from 30.7 to 22.6 (P=0.003). During the Stroop Color-Word Task, we found significantly higher levels of oxyhemoglobin changes in the prefrontal cortex of participants in the atomoxetine condition compared with those in the drug-naive condition.ConclusionsThis increase in oxyhemoglobin changes might indicate an intensified prefrontal hemodynamic response induced by atomoxetine. Near-infrared spectroscopy is a sensitive tool for measuring the pharmacological effects of atomoxetine in children with ADHD.