Extramedullary disease in patients with acute myeloid leukemia assessed by (18)F-FDG PET
Extramedullary disease in patients with acute myeloid leukemia assessed by (18)F-FDG PET
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DOI：
10.1111/ejh.12085
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发表时间：
2013-04-01
影响因子：
3.1
通讯作者：
Friis, Lone Smidstrup
中科院分区：
文献类型：
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作者：
Cribe, Anne-Sofie Weindel Ibar;Steenhof, Maria;Friis, Lone Smidstrup
急性髓系白血病（AML）诊断时髓外疾病（EMD）的患病率尚不清楚。以前的估计范围从2.5%到30.5%，通常基于临床检查。这可能导致EMD的诊断不足，因为并非所有髓外表现都容易检测。最近很少有研究使用正电子发射断层扫描（PET）诊断AML患者的EMD。方法在9个月的时间内，初诊断的AML患者谁是候选人的强化化疗前进行18F-氟脱氧葡萄糖（FDG）PET扫描诱导治疗。我们比较了通过PET扫描和临床检查诊断的EMD的患病率。诱导化疗后进行后续PET扫描，以评估EMD的反应。结果26例患者纳入研究。18-F-FDG PET扫描显示EMD患者的人数是临床检查的两倍多（65%对31%）。PET显示55个EMD病变，而临床检查诊断为15个。一般而言，PET扫描检测的EMD反应与病理检查评估的骨髓反应一致。结论18-F-FDGPET是诊断AML合并EMD及评价AML合并EMD治疗效果的有效方法。
Background Prevalence of extramedullary disease (EMD) in acute myeloid leukemia (AML) at the time of diagnosis is unknown. Previous estimates range from 2.5% to 30.5% and are usually based on clinical examination. This may cause an under diagnosis of EMD as not all extramedullary manifestations are easily detectable. Few recent studies have used positron emission tomography (PET) scans for diagnosing EMD in patients AML. Method During a 9-month period, newly diagnosed patients with AML who were candidates for intensive chemotherapy were 18F-Fluoro-deoxy-glucose (FDG) PET-scanned prior to induction treatment. We compared the prevalence of EMD diagnosed by PET scans and by clinical examination. Subsequent PET scans following induction chemotherapy were performed for response evaluation of EMD. Results Twenty-six patients were included in the study. 18-F-FDG PET scans revealed more than twice as many patients with EMD than found by clinical examination (65% vs. 31%). PET demonstrated 55 EMD lesions compared with 15 diagnosed by clinical examination. In general, the responses of EMD detected by PET scans were concordant with the bone marrow responses assessed by pathology examination. Conclusion 18-F-FDG PET is a useful tool for diagnosing EMD in AML and for assessing treatment responses of EMD in AML.