Bacillithiol: a key protective thiol in Staphylococcus aureus.
Bacillithiol: a key protective thiol in Staphylococcus aureus.
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DOI：
10.1586/14787210.2015.1064309
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发表时间：
2015
影响因子：
5.7
通讯作者：
Pogliano K
中科院分区：
文献类型：
--
作者：
Perera VR;Newton GL;Pogliano K
芽孢杆菌硫醇是一种类似于谷胱甘肽的低分子量硫醇，存在于几种厚壁菌门菌中，包括金黄色葡萄球菌。自2009年发现以来，杆菌硫醇一直是人们感兴趣的话题，因为它被发现有助于在氧化应激过程中抵抗亲电试剂（如金黄色葡萄球菌中的抗生素磷霉素）的解毒。耐甲氧西林金黄色葡萄球菌（MRSA）对现有治疗药物的耐药性迅速增加是一个重大的健康问题，许多研究工作都集中在寻找新的药物和靶点来对抗这种生物。本文综述了杆菌硫醇的发现，阐明该分子在金黄色葡萄球菌和其他芽孢杆菌中的生理作用的研究，以及细菌硫醇在金黄色葡萄球菌发病过程中对其适应性的贡献。此外，杆菌硫醇生物合成途径被评估为一种新的药物靶点，可与现有疗法联合用于治疗金黄色葡萄球菌感染。
Bacillithiol is a low-molecular-weight thiol analogous to glutathione and is found in several Firmicutes, including Staphylococcus aureus. Since its discovery in 2009, bacillithiol has been a topic of interest because it has been found to contribute to resistance during oxidative stress and detoxification of electrophiles, such as the antibiotic fosfomycin, in S. aureus. The rapid increase in resistance of methicillin-resistant Staphylococcus aureus (MRSA) to available therapeutic agents is a great health concern, and many research efforts are focused on identifying new drugs and targets to combat this organism. This review describes the discovery of bacillithiol, studies that have elucidated the physiological roles of this molecule in S. aureus and other Bacilli, and the contribution of bacillithiol to S. aureus fitness during pathogenesis. Additionally, the bacillithiol biosynthesis pathway is evaluated as a novel drug target that can be utilized in combination with existing therapies to treat S. aureus infections.