Palladium-catalyzed cross-coupling reactions of in situ generated allylindium reagents with aryl halides
Palladium-catalyzed cross-coupling reactions of in situ generated allylindium reagents with aryl halides
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DOI：
10.1021/ol016532h
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发表时间：
2001-10-04
期刊：
影响因子：
5.2
通讯作者：
Lee, K
中科院分区：
文献类型：
--
作者：
Lee, PH;Sung, SY;Lee, K
1当量的铟与1.5当量的烯丙基卤反应原位生成的烯丙基铟试剂可以在钯催化的芳基卤的交叉偶联反应中成为有效的交叉偶联伙伴。当Pd（2）dba（3）CHCl（3）和Ph3P的质量分数为2%时，在100 ℃下，LiCl的DMF溶液中加入3当量LiCl，可得到最好的结果。
GRAPHICSIn situ generated allylindium reagents from the reaction of 1 equiv of indium with 1.5 equiv of allyl halides could be effective cross-coupling partners in palladium-catalyzed cross-coupling reactions to aryl halides. The best results were obtained with 2% Pd(2)dba(3)CHCl(3) and 16% Ph3P in the presence of 3 equiv of LiCl in DMF at 100 degreesC.