Coordinated Networks of microRNAs and Transcription Factors with Evolutionary Perspectives
Coordinated Networks of microRNAs and Transcription Factors with Evolutionary Perspectives
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DOI：
10.1007/978-94-007-5590-1_10
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发表时间：
2013-01-01
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影响因子：
--
通讯作者：
Iwama, Hisakazu
中科院分区：
文献类型：
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作者：
Iwama, Hisakazu
microrna （mirna）和转录因子（tf）是基因调控网络中的两大类反式调控因子。mirna和tf之间的协调性已经在各种癌症的发育过程和发病机制的个别研究中得到证实。系统计算方法在阐明miRNA-TF协同调控的全局网络特征方面具有优势。mirna和tf具有不同的分子和进化特性。特别是，miRNA基因在进化过程中具有快速的生与死转换过程，其影响广泛但适度。因此，mirna和tf被认为对它们的协调有不同的贡献。miRNA-TF协调的前馈电路被认为会导致冗余的显著增加，但会大大减少靶基因库，这就提出了一个问题，miRNA-TF协调在多大程度上是有益的？进化分析在系统水平上为miRNA-TF协调调节网络的特征提供了广阔的视角。
MicroRNAs (miRNAs) and transcription factors (TFs) are two major classes of trans-regulators in gene regulatory networks. Coordination between miRNAs and TFs has been demonstrated by individual studies on developmental processes and the pathogenesis of various cancers. Systematic computational approaches have an advantage in elucidating global network features of the miRNA-TF coordinated regulation. miRNAs and TFs have distinct molecular and evolutionary properties. In particular, miRNA genes have a rapid turnover of birth-and-death processes during evolution, and their effects are widespread but modest. Therefore, miRNAs and TFs are considered to have different contributions to their coordination. The miRNA-TF coordinated feedforward circuits are considered to cause significant increases in redundancy but drastically reduce the target gene repertoire, which poses the question, to what extent is miRNA-TF coordination beneficial? Evolutionary analyses provide wide perspectives on the features of miRNA-TF coordinated regulatory networks at a systems level.