Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon.
Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon.
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DOI：
10.1016/j.biopha.2021.112137
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
de Barros ALB
中科院分区：
文献类型：
--
作者：
de Alcantara Lemos J;Oliveira AEMFM;Araujo RS;Townsend DM;Ferreira LAM;de Barros ALB
在过去的几十年里，制药工业对药用植物的利用导致了许多新的生物活性化合物的鉴定。翼龙属，原产于巴西植物群，以其物种的治疗特性而闻名，其广泛用于大众医学中的抗炎，抗风湿，滋补和净化特性。该属植物衍生物固有的低水溶性，包括具有与药理活性部分相关的vouacapane骨架的二萜，损害了这些生物活性化合物的生物利用度。最近的研究旨在封装Pterodon产品，以提高其水溶性，实现稳定性，增加其功效，并允许临床应用。本文的目的是审查最近的研究使用纳米技术的新产品的开发，从植物衍生物的翼龙属在不同类型的微和纳米载体。还介绍了它们不同产品的治疗特性。最后，提供了关于胶囊制剂的当前和未来应用的更新。
In the last few decades, utilization of medicinal plants by the pharmaceutical industry has led to the identification of many new bioactive compounds. The genus Pterodon, native of the Brazilian Flora, is known for the therapeutic properties attributed to its species, which are widely used in popular medicine for their anti-inflammatory, anti-rheumatic, tonic, and depurative properties. The intrinsic low water solubility of the plant derivatives from the genus, including diterpenes with vouacapane skeletons that are partially associated with the pharmacological activities, impairs the bioavailability of these bioactive compounds. Recent studies have aimed to encapsulate Pterodon products to improve their water solubility, achieve stability, increase their efficacy, and allow clinical applications. The purpose of this paper is to review recent research on the use of nanotechnology for the development of new products from plant derivatives of the Pterodon genus in different types of micro- and nanocarriers. Therapeutic properties of their different products are also presented. Finally, an update about the current and future applications of encapsulated formulations is provided.
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DOI：
10.1590/s0102-695x2013005000016
发表时间：
2013-04-01
期刊：
Revista Brasileira de Farmacognosia
影响因子：
--
作者：
Alves, Suzana F.;Borges, Leonardo Luiz;Bara, Maria Teresa Freitas
通讯作者：
Bara, Maria Teresa Freitas
影响因子：
1.4
作者：
Belinelo, Valdenir J.;Reis, Genuína T.;Piló-Veloso, Dorila
通讯作者：
Piló-Veloso, Dorila
影响因子：
--
作者：
Ashraf MA;Peng W;Zare Y;Rhee KY
通讯作者：
Rhee KY
影响因子：
8
作者：
Bozzuto G;Molinari A
通讯作者：
Molinari A
影响因子：
16
作者：
Atanasov AG;Waltenberger B;Pferschy-Wenzig EM;Linder T;Wawrosch C;Uhrin P;Temml V;Wang L;Schwaiger S;Heiss EH;Rollinger JM;Schuster D;Breuss JM;Bochkov V;Mihovilovic MD;Kopp B;Bauer R;Dirsch VM;Stuppner H
通讯作者：
Stuppner H