A new approach to postoperative peritoneal adhesions: Prevention of peritoneal trauma by aloe vera gel
A new approach to postoperative peritoneal adhesions: Prevention of peritoneal trauma by aloe vera gel
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DOI：
10.1016/j.ejogrb.2009.11.019
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发表时间：
2010-04-01
影响因子：
2.6
通讯作者：
Ersoz, Feyzullah
中科院分区：
文献类型：
--
作者：
Aysan, Erhan;Bektas, Hasan;Ersoz, Feyzullah
目的：研究设计：将40只Wistar白化病远系繁殖雌性大鼠（平均体重，180 +/-25 g;平均年龄，6个月）分成4组。第1组腹腔注射芦荟凝胶0.1mL。在第2组中，诱导腹膜粘连。第3组，诱导粘连，用0.1 mL芦荟凝胶覆盖模型区域。在第4组中，在粘连诱导之前用芦荟凝胶覆盖该区域。术后第10天处死大鼠，在显微镜和肉眼下对粘连进行评分。四组的平均肉眼粘连评分分别为0、5.8 ± 0.42、5.2 ± 0.79和1.1 ± 1.2，组4与组2（p < 0.001）和组3（p < 0.05）之间的差异具有统计学显著性。第3组的平均组织病理学纤维化值显著高于第4组（2.6 +/- 0.51 vs 1.2 +/- 0.91，p = 0.002）。结论：如果在腹膜创伤之前而不是之后应用芦荟凝胶，则可以有效减少粘连形成。这种效果可能不是由于其化学性质，而是由于其粘度，提供了一个覆盖，以防止腹膜创伤。皇冠版权所有（C）2009由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: Covering peritoneal surfaces with aloe vera gel may prevent peritoneal trauma and hence postoperative peritoneal adhesions.Study design: Forty Wistar albino out-bred female rats (mean weight, 180 +/- 25 g: mean age, 6 months) were divided into four groups. In Group 1, 0.1 mL aloe vera gel was injected into the peritoneal cavities. In Group 2, peritoneal adhesions were induced. In Group 3, adhesions were induced and the modeled area was covered by 0.1 mL aloe vera gel. In Group 4, the area was covered with aloe vera gel prior to adhesion induction. The rats were sacrificed on postoperative day 10 and the adhesions were scored both microscopically and macroscopically.Results: The mean macroscopic adhesion score in the four groups was 0, 5.8 +/- 0.42, 5.2 +/- 0.79, and 1.1 +/- 1.2 respectively, with the difference between Group 4 and Groups 2 (p < 0.001) and 3 (p < 0.05) statistically significant. The mean histopathological fibrosis values were significantly higher in Group 3 than in Group 4 (2.6 +/- 0.51 vs 1.2 +/- 0.91, p = 0.002).Conclusion: Aloe vera gel can effectively decrease adhesion formation if applied before, but not after, after peritoneal trauma. This effect is likely due not to its chemical properties but to its viscosity, providing a covering to prevent peritoneal trauma. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.