Inhibition of epinephrine oxidation in weak alkaline solutions.
Inhibition of epinephrine oxidation in weak alkaline solutions.
复制标题
在弱碱性溶液中抑制肾上腺素氧化。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
L. Balint
中科院分区：
文献类型：
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作者：
R. Bonevski;J. Momirovic;L. Balint
研究了焦亚硫酸钠和半胱氨酸在弱碱性溶液中对肾上腺素氧化的影响。还测量了反应混合物的荧光强度。浓度低于3 x 10(-5) M的2 x 10(-3) M NaOH中的焦亚硫酸钠对肾上腺素氧化没有影响；然而，当浓度从 5 x 10(-5) 到 3 x 10(-4) M 时，它大大加速了这一过程。其抑制作用仅在浓度大于 5 x 10(-4) M 时出现。这些反应的机制也得到了解释。 2 x 10(-3) M NaOH 中的半胱氨酸即使浓度为 7 x 10(-5) M 也能抑制肾上腺素的氧化。
The effect of sodium metabisulfite and cysteine on the oxidation of epinephrine in weak alkaline solutions was studied. The fluorescent intensity of the reacting mixture also was measured. Sodium metabisulfite in 2 x 10(-3) M NaOH at concentrations lower than 3 x 10(-5) M had no effect on epinephrine oxidation; however, in concentrations from 5 x 10(-5) to 3 x 10(-4) M, it greatly accelerated this process. Its inhibitory action appeared only in concentrations greater than 5 x 10(-4) M. The mechanism of these reactions also was explained. Cysteine in 2 x 10(-3) M NaOH inhibited the oxidation of epinephrine even in concentrations of 7 x 10(-5) M.