Light at night and breast cancer risk: results from a population-based case-control study in Connecticut, USA
Light at night and breast cancer risk: results from a population-based case-control study in Connecticut, USA
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DOI：
10.1007/s10552-010-9653-z
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发表时间：
2010-12-01
影响因子：
2.3
通讯作者：
Dai, Min
中科院分区：
文献类型：
--
作者：
Li, Qian;Zheng, Tongzhang;Dai, Min
目的探讨家庭夜间光照（LAN）与人类乳腺癌发病风险之间的潜在关系。方法在康涅狄格州进行女性乳腺癌病例对照研究。共363例乳腺癌病例和356例年龄频率匹配的对照组进行了采访，使用标准化的，结构化的问卷调查，以获得有关睡眠模式和卧室光环境的信息。结果绝经后妇女睡觉时开灯与乳腺癌的发生率无显著性差异（P > 0. 05（OR = 1.4，95%CI 0.7，2.7），报告白天主要睡眠者（OR = 1.4，95% CI 0.5，4.3），夜间睡觉时不拉窗帘/窗帘者结论本研究结果提示，家庭接触LAN可能增加乳腺癌的危险性。需要更大样本量的进一步研究来证实结果。
Objective To investigate the potential association between domestic exposure to light at night (LAN) and the risk of human breast cancer.Methods A case-control study of female breast cancer was conducted in Connecticut. A total of 363 incident breast cancer cases and 356 age frequency-matched controls were interviewed using a standardized, structured questionnaire to obtain information on sleeping patterns and bedroom light environment. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multivariate logistic regression.Results A non-significantly increased risk of breast cancer was observed among postmenopausal women for those keeping lights on while sleeping (OR = 1.4, 95% CI 0.7, 2.7), those who reported mainly sleeping in the daytime (OR = 1.4, 95% CI 0.5, 4.3), and those not drawing the curtains/window shades while sleeping at night (OR = 1.2, 95% CI 0.8, 1.9).Conclusion The results from this study suggest a potential increased risk of breast cancer associated with domestic exposure to LAN. Further studies with larger sample size are needed to confirm the results.