Comparison of magnesium alloys and poly-l-lactide screws as degradable implants in a canine fracture model
Comparison of magnesium alloys and poly-l-lactide screws as degradable implants in a canine fracture model
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DOI：
10.1002/jbm.b.33470
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发表时间：
2016-10-01
影响因子：
3.4
通讯作者：
Harada, Hiroyuki
中科院分区：
文献类型：
--
作者：
Marukawa, Eriko;Tamai, Masato;Harada, Hiroyuki
本研究的目的是评价由可生物降解阳极氧化WE 43（含镁钇、稀土元素和锆; Elektron SynerMag（R））镁合金、整体式WE 43镁合金和聚-l-乳酸（PLLA）组成的植入物的体内生物学反应，这些材料是临床环境中常用的材料，并评价这些材料作为骨螺钉的有效性。使用涉及比格犬胫骨的骨折模型评价镁合金植入物在接骨术中的有效性。对于整体式WE 43植入物，放射学和组织学评价显示，由于炎症反应，植入的整体式WE 43周围的骨小梁减少。然而，阳极氧化WE 43植入物周围的骨组织中没有因氢气或炎症反应而造成的损伤。4周后，所有PLLA种植体（n=3）均断裂，但WE 43种植体（n=6）未断裂。这些结果表明，WE 43种植体具有足够的强度，可在骨科和口腔颌面外科手术中固定承重部位的骨折。因此，这些可生物降解的镁合金是替代可生物降解聚合物的良好候选物。(c)2015 Wiley Periodicals，Inc. J Biomed Mater Res Part B：Appl Biomater，104 B：1282-1289，2016。
The aims of this study were to evaluate in vivo the biological responses to implants composed of biodegradable anodized WE43 (containing magnesium yttrium, rare earth elements and zirconium; Elektron SynerMag (R)) magnesium alloy, monolithic WE43 magnesium alloy and poly-l-lactic acid (PLLA), which are commonly used materials in clinic settings, and to evaluate the effectiveness of the materials as bone screws. The effectiveness of the magnesium alloy implants in osteosynthesis was evaluated using a bone fracture model involving the tibia of beagle dogs. For the monolithic WE43 implants, radiological, and histological evaluation revealed that bone trabeculae around the implanted monolithic WE43 decreased because of an inflammatory response. However, there was no damage due to hydrogen gas or inflammatory response in the bone tissue around the anodized WE43 implants. After 4 weeks, all the PLLA implants (n=3) had broken but the WE43 implants had not (n=6). These results suggest that the WE43 implants had sufficient strength to fix bone fractures at load-bearing sites in orthopedic and oral maxillofacial surgery. Therefore, these biodegradable magnesium alloys are good candidates for replacing biodegradable polymers. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1282-1289, 2016.