Plasma homocysteine levels and folate status in children with sickle cell anemia.
Plasma homocysteine levels and folate status in children with sickle cell anemia.
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镰状细胞性贫血儿童的血浆同型半胱氨酸水平和叶酸状态。
DOI：
10.1097/00043426-199905000-00010
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Buchanan,GR
中科院分区：
文献类型：
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作者：
Rodriguez-Cortes,HM;Griener,JC;Hyland,K;Bottiglieri,T;Bennett,MJ;Kamen,BA;Buchanan,GR
目的：血浆同型半胱氨酸浓度与叶酸状态之间存在敏感的负相关关系。尽管患有镰状细胞性贫血(SCA)的儿童存在叶酸缺乏的潜在风险，但此类患者的血浆同型半胱氨酸水平尚未见报道。因此，一项研究旨在评估血浆同型半胱氨酸水平作为叶酸状态的标志。设计：对120名从未服用叶酸补充剂的SCA儿童(102名处于稳定状态，18名在急性并发症期间)进行血浆同型半胱氨酸水平的测定。结果：SCA患者和对照组的血浆同型半胱氨酸水平相似。SCA组+/-1标准差为5.8+/-2.5mil/L/L(1.6~14.1mil/L)，73例对照组为6.1+/-2.7mil/L(1.70~15.3mol/L)。在研究组的一个亚群(34名儿童)中，还同时测量了血清叶酸、红细胞叶酸和总同型半胱氨酸浓度。血清叶酸和红细胞叶酸浓度正常：分别为12.4+/-10.0nmol/L(范围：1~42nmol/L)和604+/-374.7 nmol/L(范围：205~1741nmol/L)。血浆同型半胱氨酸浓度与各种临床或实验室指标或红细胞叶酸浓度之间没有相关性。结论：尽管有潜在的溶血性贫血，但没有接受叶酸补充的SCA儿童的叶酸储备是充足的。
Purpose: A sensitive inverse relationship between plasma homocysteine concentration and folate status has been demonstrated. Although children with sickle cell anemia (SCA) are at potential risk for folate deficiency, plasma homocysteine levels have not been reported in such patients. Therefore, a study was designed to assess plasma homocysteine levels as a marker of folate status.Design: Plasma homocysteine concentrations were measured in 120 children with SCA (102 in steady state and 18 during an acute complication) who had never received supplemental folic acid. Folate status was directly assessed in 34 of these patients.Results: Plasma homocysteine levels in the patients with SCA and control subjects were similar. The mean value+/-1 SD was 5.8+/-2.5 [mu] mil/L/L (range, 1.6 to 14.1 [mu] mol/L) in the patients with SCA and 6.1+/-2.7 [mu] mil/L (range, 1.7 to 15.3 [mu] mol/L) in 73 pediatric control subjects. In a subpopulation of the study group (34 children), simultaneous serum folate, red cell folate, and total homocysteine concentrations were also measured. Their serum folate and red cell folate concentrations were normal: 12.4+/-10.0 nmol/L (range, 1 to 42 nmol/L) and 604+/-374.7 nmol/L (range, 205 to 1741 nmol/L), respectively. There was no correlation of plasma homocysteine concentration with various clinical or laboratory measures or with red cell folate concentration.Conclusion: Folate stores in children with SCA not receiving folic acid supplements are adequate despite an underlying hemolytic anemia.