Low-Level Laser Therapy Prevents Treadmill Exercise-Induced Progression of Arthrogenic Joint Contracture Via Attenuation of Inflammation and Fibrosis in Remobilized Rat Knees
Low-Level Laser Therapy Prevents Treadmill Exercise-Induced Progression of Arthrogenic Joint Contracture Via Attenuation of Inflammation and Fibrosis in Remobilized Rat Knees
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DOI：
10.1007/s10753-018-0941-1
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发表时间：
2019-06-01
期刊：
影响因子：
5.1
通讯作者：
Yamaoka, Kaoru
中科院分区：
文献类型：
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作者：
Kaneguchi, Akinori;Ozawa, Junya;Yamaoka, Kaoru
我们调查了使用低强度激光疗法(LLLT)的运动和抗炎/抗纤维化治疗的结合是否促进了关节痉挛的恢复而没有关节源性痉挛的进展。大鼠屈膝位制动3周。取下固定器后，将大鼠分为不干预组(RM)、每日跑台步行组(Wk)、每日跑台步行+低剂量LLLT组(W+L)。在肌切开术前(m-ROM)和切开肌切开术(a-ROM)后，分别用被动活动范围限制(ROM)评价完全性和关节源性肌挛缩。再动员7d后，各组m-ROM受限程度均有不同程度的降低。相反，在Rm组和Walk组，再动员后a-ROM限制进一步增加。此外，与RM组相比，步行组的这种限制明显更大。然而，W+L组阻止了再动员过程中a-ROM限制的进展。再动员1d或7d后，RM组关节囊内出现炎症和纤维化反应，步行组明显，W+L组较步行组轻。最初通过固定建立的代表完全性肌挛缩的M-ROM限制通过再动员得到部分改善。额外的LLLT和运动干预并没有进一步减少完全的痉挛，但LLLT抑制了由步行和跑步机运动引起的关节源性痉挛的进展。因此，在关节松弛的早期阶段进行LLLT锻炼将是防止关节源性痉挛进一步发展的一种可能的辅助治疗。
We investigated whether the combination of exercise and anti-inflammatory/anti-fibrotic treatment using low-level laser therapy (LLLT) promotes recovery from joint contracture without arthrogenic contracture progression. Rat knees were immobilized for 3weeks in a flexed position. After fixator removal, rats were divided into no intervention (RM), daily treadmill walking (WALK), and daily treadmill walking and LLLT (W+L) groups. Total and arthrogenic contractures were assessed by restrictions of passive range of motion (ROM) before (m-ROM) and after myotomy (a-ROM), respectively. After 7days of remobilization, m-ROM restriction decreased equally in all groups. Conversely, a-ROM restriction further increased after remobilization in the RM and WALK groups. Furthermore, this restriction was significantly larger in the WALK group compared with the RM group. In the W+L group, however, progression of a-ROM restriction during remobilization was prevented. After 1 or 7days of remobilization, inflammatory and fibrotic reactions in the joint capsule were induced in the RM group and were more pronounced in the WALK group, but these reactions were milder in the W+L group than in the WALK group. m-ROM restriction representing total contracture initially established by immobilization was partially improved by remobilization. Additional LLLT and exercise intervention did not further reduce total contracture, but LLLT suppressed the progression of arthrogenic contracture caused by ambulation and treadmill exercise. Therefore, exercise with LLLT in the early phase of remobilization would be one possible adjunct therapy to prevent further progression of arthrogenic contracture.