Near-infrared emission carbon dots for bio-imaging applications
Near-infrared emission carbon dots for bio-imaging applications
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DOI：
10.1016/s1872-5805(21)60041-0
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发表时间：
2021-06-18
影响因子：
5.7
通讯作者：
Zhang, Rui-ping
中科院分区：
文献类型：
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作者：
Li, Li-ping;Ren, Xiao-feng;Zhang, Rui-ping
制备用于生物成像应用的红色/近红外发射碳量子点（CD）是非常困难的，这是由于它们的深组织穿透、最小的自发荧光和对生物组织的低发射光损伤而需要的。以磺化四苯基卟啉为原料，采用溶剂热法合成了具有近红外发射的染料。它们具有与激发无关的性质，最大发射波长为692 nm。研究表明，这种独特的近红外发射主要来源于CD分子的聚集态。NIR-CD显示出良好的水溶性、优异的生物相容性、低毒性和上级的细胞标记能力。这项工作可以大大推进近红外光盘的结构设计和制备以及相应的生物成像应用。
It is very difficult to prepare red/near-infrared emission carbon dots (CDs) for bio-imaging applications which are needed because of their deep tissue penetration, minimal auto-fluorescence, and low emission light damage to bio-tissues. Near-infrared emitting CDs (NIR-CDs) were synthesized from sulfonated tetraphenylporphyrin using a solvothermal method. They have excitation-independent properties with a maximum emission at 692 nm. Studies showed that this unique near-infrared emission mainly originated from the aggregated molecular states of the CDs. The NIR-CDs showed good water solubility, exceptional biocompatibility, low toxicity, and superior cellular labelling ability. This work could significantly advance the structural design and preparation of NIR-CDs and corresponding bio-imaging applications.