DISCOVERY OF HUMAN ZINC-DEFICIENCY AND STUDIES IN AN EXPERIMENTAL HUMAN-MODEL
DISCOVERY OF HUMAN ZINC-DEFICIENCY AND STUDIES IN AN EXPERIMENTAL HUMAN-MODEL
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DOI：
10.1093/ajcn/53.2.403
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发表时间：
1991-02-01
影响因子：
7.1
通讯作者：
PRASAD, AS
中科院分区：
文献类型：
--
作者：
PRASAD, AS
锌对人类健康的重要性最早于1963年被记录。在过去的25年中，由于营养因素和几种疾病状态导致的人类锌缺乏已经被认识到，已知谷物蛋白中的高植酸含量会降低锌的可用性，因此在消耗大量谷物蛋白的人群中锌缺乏的患病率可能很高。酒精中毒、吸收不良、镰状细胞性贫血、慢性肾脏疾病和慢性衰弱性疾病现在已知是缺锌的诱发因素。人类缺锌症的临床表现从轻度到重度不等。锌是许多生物功能所必需的，包括DNA合成，细胞分裂和基因表达。它是生物系统中许多酶的活性所必需的。最近的研究表明，锌是细胞介导的免疫所必需的。
The importance of zinc for human health was first documented in 1963. During the past 25 y, deficiency of zinc in humans due to nutritional factors and several disease states has now been recognized.The high phytate content of cereal proteins is known to decrease the availability of zinc, thus the prevalence of zinc deficiency is likely to be high in a population consuming large quantities of cereal proteins. Alcoholism, malabsorption, sickle cell anemia, chronic renal disease, and chronically debilitating diseases are now known to be predisposing factors for zinc deficiency. A spectrum of clinical manifestations ranging from mild to severe degree have now been recognized in human zinc-deficiency states. Zinc is required for many biological functions including DNA synthesis, cell division, and gene expression. It is required for the activity of many enzymes in biological systems. Recent studies indicate that zinc is needed for cell-mediated immunity.