Components of the "metabolic syndrome" and incidence of type 2 diabetes
Components of the "metabolic syndrome" and incidence of type 2 diabetes
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DOI：
10.2337/diabetes.51.10.3120
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发表时间：
2002-10-01
期刊：
影响因子：
7.7
通讯作者：
Knowler, WC
中科院分区：
文献类型：
--
作者：
Hanson, RL;Imperatore, G;Knowler, WC
胰岛素抵抗、血脂异常、高血压和肥胖的组合被描述为“代谢综合征”，这是 2 型糖尿病的一个强有力的决定因素。使用因子分析来确定 1,918 名皮马印第安人中该综合征的组成部分。进行前瞻性分析以评估已确定因素与糖尿病发病率的关联。因子分析确定了 4 个因素，这些因素占原始 10 个变量中方差的 79%。每个因素都反映了代谢综合征的一个拟议组成部分：胰岛素血症、在 890 名原本没有糖尿病的参与者中，平均随访 4.1 年，其中 144 人患上糖尿病。胰岛素血症因素与糖尿病发病率（1-SD 的发病率比 [IRR]）差异显着 = 1.81，P < 0.01）。分别为 1.37，P < 0.01），而血压因素却没有（IRR 1.11，P = 0.20）。对与糖尿病发病率具有不同关联的四个独特因素的识别表明，这些变量之间的相关性反映了不同的代谢过程，在尝试将它们合并为一个实体时可能会丢失大量信息。
The combination of insulin resistance, dyslipidemia, hypertension, and obesity has been described as a metabolic syndrome" that is A strong determinant of type 2 diabetes. Factor analysis was used to identify components of this syndrome in 1,918 Pima Indians. Prospective analyses were conducted to evaluate associations of identified factors with incidence of diabetes. Factor analysis identified 4 factors that accounted for 79% of the variance in the original 10, variables. Each of these factors reflected a proposed component of the metabolic syndrome: insulinemia, body size, blood pressure, and lipid metabolism. Among 890 originally nondiabetic participants with follow-up data, 144 developed. diabetes in a median follow-up of 4.1 years. The insulinemia factor was strongly associated with diabetes incidence (incidence rate ratio [IRR] for a 1-SD) difference in factor scores = 1.81, P < 0.01). The body size and lipids factors also significantly predicted diabetes (IRR 1.52 and 1.37, respectively, P < 0.01 for both), whereas the blood pressure factor did not (IRR 1.11, P = 0.20). Identification of four unique factors with different associations with incidence of diabetes suggests that the correlations among these variables reflect distinct metabolic processes, about which substantial information may be lost in the attempt to combine them into a single entity.