Enantioselective Protonation of Carbanions with Chiral Proton Sources
Enantioselective Protonation of Carbanions with Chiral Proton Sources
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手性质子源对碳负离子的对映选择性质子化
DOI：
10.1002/anie.198712831
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发表时间：
1987
影响因子：
--
通讯作者：
S. Hünig
中科院分区：
文献类型：
--
作者：
U. Gerlach;S. Hünig
手性质子源X* H的α-羟基羧酸结构单元保证了环酯烯醇化物1的质子化中的最大对映选择性。在1与氨基锂的合成中形成的胺几乎不影响质子化的选择性。碱金属和溶剂的变化揭示了1的接触结构对于高选择性是必不可少的。达到的最高评价是。百分之五十
An α‐hydroxycarboxylic acid structural unit of the chiral proton source X* H guarantees the greatest enantioselectivity in the protonation of the cyclic ester enolate 1. Amines which are formed in the synthesis of 1 with lithium amides hardly influence the selectivity of the protonation. Variation of the alkali metal and of the solvent revealed that a contaction structure of 1 is essential for high selectivities. The highest eevalues achieved are ca. 50%.