Insights into APC/C: from cellular function to diseases and therapeutics.
Insights into APC/C: from cellular function to diseases and therapeutics.
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DOI：
10.1186/s13008-016-0021-6
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发表时间：
2016
期刊：
影响因子：
2.3
通讯作者：
Wan Y
中科院分区：
文献类型：
--
作者：
Zhou Z;He M;Shah AA;Wan Y
后期促进复合物/环体 (APC/C) 是一种多功能泛素蛋白连接酶，针对不同的底物进行泛素化，从而调节多种细胞过程，如细胞分裂、分化、基因组稳定性、能量代谢、细胞死亡、自噬以及癌变。 APC/C 的活性主要由细胞周期内外的两种 WD-40 结构域蛋白 Cdc20 和 Cdh1 控制。在过去的十年中，基于大量生化、3D 结构、小鼠遗传和小分子抑制剂研究的结果在很大程度上吸引了我们对 APC/C 的新兴作用及其在生物功能、人类疾病和潜在治疗中的调节的关注。本综述旨在总结最近报道的一些关于 APC/C 在调节细胞功能、其功能障碍与人类疾病的联系及其治疗意义的见解。
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome stability, energy metabolism, cell death, autophagy as well as carcinogenesis. Activity of APC/C is principally governed by two WD-40 domain proteins, Cdc20 and Cdh1, in and beyond cell cycle. In the past decade, the results based on numerous biochemical, 3D structural, mouse genetic and small molecule inhibitor studies have largely attracted our attention into the emerging role of APC/C and its regulation in biological function, human diseases and potential therapeutics. This review will aim to summarize some recently reported insights into APC/C in regulating cellular function, connection of its dysfunction with human diseases and its implication of therapeutics.