The Role of Inflammation in Age-Related Sarcopenia.
The Role of Inflammation in Age-Related Sarcopenia.
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DOI：
10.3389/fphys.2017.01045
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发表时间：
2017
影响因子：
4
通讯作者：
Koppo K
中科院分区：
文献类型：
--
作者：
Dalle S;Rossmeislova L;Koppo K
随着年龄的增长，会发生许多生理变化。这些变化往往直接或间接地导致生活质量下降，甚至缩短预期寿命。除了活性氧水平升高、DNA损伤和细胞凋亡外，影响衰老过程的另一个重要因素涉及系统性慢性低度炎症。这种情况已经被证明与几种(亚)临床情况相关，如胰岛素抵抗、动脉粥样硬化和阿尔茨海默病。然而，最近的证据表明，慢性低度炎症也导致肌肉质量、力量和功能的丧失，称为肌萎缩症，因为它通过几个信号通路影响肌肉蛋白质的分解和合成。对抗与年龄相关的肌肉萎缩的经典干预措施主要集中在抵抗力训练和/或蛋白质补充，以克服老年人患有的合成代谢不灵活。虽然老年人从这些经典的干预措施中受益，但抗炎策略的治疗潜力引起了极大的兴趣，因为这些策略可能加在一起/支持抵抗运动和/或补充蛋白质的合成代谢效果。在这篇综述中，将讨论炎症、合成代谢敏感性和肌肉蛋白代谢之间的分子相互作用。
Many physiological changes occur with aging. These changes often, directly or indirectly, result in a deterioration of the quality of life and even in a shortening of life expectancy. Besides increased levels of reactive oxygen species, DNA damage and cell apoptosis, another important factor affecting the aging process involves a systemic chronic low-grade inflammation. This condition has already been shown to be interrelated with several (sub)clinical conditions, such as insulin resistance, atherosclerosis and Alzheimer's disease. Recent evidence, however, shows that chronic low-grade inflammation also contributes to the loss of muscle mass, strength and functionality, referred to as sarcopenia, as it affects both muscle protein breakdown and synthesis through several signaling pathways. Classic interventions to counteract age-related muscle wasting mainly focus on resistance training and/or protein supplementation to overcome the anabolic inflexibility from which elderly suffer. Although the elderly benefit from these classic interventions, the therapeutic potential of anti-inflammatory strategies is of great interest, as these might add up to/support the anabolic effect of resistance exercise and/or protein supplementation. In this review, the molecular interaction between inflammation, anabolic sensitivity and muscle protein metabolism in sarcopenic elderly will be addressed.
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影响因子：
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