Correlation between Exposure to Magnetic Fields and Embryonic Development in the First Trimester
Correlation between Exposure to Magnetic Fields and Embryonic Development in the First Trimester
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DOI：
10.1371/journal.pone.0101050
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发表时间：
2014-06-30
期刊：
影响因子：
3.7
通讯作者：
Miao, Mao-Hua
中科院分区：
文献类型：
--
作者：
Su, Xiu-Juan;Yuan, Wei;Miao, Mao-Hua
目的：探讨日常生活中母体磁场暴露与胚胎发育的关系。方法：对149例因意外怀孕寻求人工流产的孕妇进行横断面研究。参与的妇女被要求佩戴EMDEX Lite磁场计24小时，以获得流产后4周内的MF暴露水平。手术流产前通过b超测量胚胎芽和胚囊长度。制备胚胎切片，观察组织学变化，采用TUNEL细胞凋亡法检测蜕膜的凋亡状态。结果：胚胎芽长与母体每日MF暴露水平呈负相关；在时间加权平均值和第75百分位暴露水平上，相关性具有统计学意义，系数分别为-3.09 （P = 0.0479）和-3.07（P = 0.0228）。用于检查较高MF暴露风险的逻辑回归表明，每日MF测量值为第75百分位的妇女>= 0.82 mG，其胎儿胚胎芽长较短的风险是每日MF暴露值为0.82 mG的妇女的3.95倍
Objective: To explore the correlation between maternal magnetic field (MF) exposure in daily life and embryonic development.Methods: A cross-sectional study was conducted among 149 pregnant women who were seeking induced abortion of unwanted pregnancies. Participating women were asked to wear an EMDEX Lite magnetic field meter for a 24-h period to obtain MF exposure level within 4 weeks following the abortion. Embryonic bud and sac lengths were measured through B-mode ultrasound before the surgical abortion. Embryo sections were prepared and examined for histological changes, and the apoptosis status of the deciduas was examined using the TUNEL apoptosis assay.Results: Embryonic bud length was inversely associated with maternal daily MF exposure level; the association was statistically significant at the time-weighted-average and 75th percentile of MF exposure levels, with coefficients of -3.09 (P = 0.0479) and -3.07(P = 0.0228), respectively. Logistic regression for examining the risk of higher MF exposure indicated that women with her 75th percentile of daily MF measurements >= 0.82 mG had a 3.95-fold risk of having a fetus with a shorter embryonic bud length than those whose daily MF exposure were