GROWTH-FACTORS AND CANCER
GROWTH-FACTORS AND CANCER
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DOI：
10.1126/science.1659742
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发表时间：
1991-11-22
期刊：
影响因子：
56.9
通讯作者：
AARONSON, SA
中科院分区：
文献类型：
--
作者：
AARONSON, SA
介导生长因子正常功能的信号通路通常在癌症中被破坏。通过各种方法鉴定的癌基因已被证明在促有丝分裂信号传导的关键步骤中起作用。细胞周期的进展需要两种互补的生长因子的成员的协调作用，而癌基因似乎取代了一组这些生长因子的作用。生长因子也可以影响正常细胞分化，并且癌细胞中生长促进途径的组成性激活也可以调节细胞表型。生长因子和细胞因子的旁分泌作用也可能影响导致恶性肿瘤的一系列逐步遗传事件。正在开发新的癌症治疗方法，干预生长因子信号通路的各个步骤。
Signaling pathways that mediate the normal functions of growth factors are commonly subverted in cancer. Oncogenes identified by a variety of approaches have been shown to function at critical steps in mitogenic signaling. Progression through the cell cycle requires the coordinated actions of members of two complementary classes of growth factors, and oncogenes appear to replace the actions of one set of these growth factors. Growth factors can also influence normal cell differentiation, and constitutive activation of growth-promoting pathways in cancer cells can modulate the cell phenotype as well. Paracrine actions of growth factors and cytokines may also influence the stepwise series of genetic events that lead to malignancy. New approaches for cancer therapy are being developed that intervene at various steps in growth factor signaling pathways.