Emergence of a Salmonella Rissen ST469 clinical isolate carrying bla (NDM-13) in China.
Emergence of a Salmonella Rissen ST469 clinical isolate carrying bla (NDM-13) in China.
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中国出现携带 blaNDM-13 的沙门氏菌 Rissen ST469 临床分离株
DOI：
10.3389/fcimb.2022.936649
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
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作者：
新德里金属 - β-内酰胺酶-13（NDM-13）是一种NDM变体，在此研究之前，在沙门氏菌物种中尚未发现，我们描述了rissen rissen菌株SR33的首次识别，该菌株携带BLA NDM-13的目标是SR的属性。 NDM-13。从发烧和腹泻的患者中分离出SR33的SR33菌株。 3-SR33。从GenBank下载的NDM-13阳性基因组表明，遗传环境（ΔISABA125-BLA NDM-13-13-BLE MBL-TRPF）和混合启动子（由ISABA125和-10序列提供的-35个序列（由ISABA125和-10序列）配置为33 pla ins-iS125。 -sr33。据我们所知，这是BLA NDM-13沙门氏菌。在临床MDR S.
New Delhi metallo-β-lactamase-13 (NDM-13) is an NDM variant that was first identified in 2015 and has not been detected in Salmonella species prior to this study. Here we describe the first identification of a Salmonella Rissen strain SR33 carrying bla NDM-13. The aim of this study was to molecularly characterize SR33’s antimicrobial resistance and virulence features as well as investigate the genetic environment of bla NDM-13. The Salmonella Rissen SR33 strain was isolated from a patient with fever and diarrhea. SR33 belonged to ST469, and it was found to be multidrug-resistant (MDR) and to carry many virulence genes. Phylogenetic analysis showed that SR33 shared a close relationship with most of the Chinese S. Rissen ST469 strains. bla NDM-13 was located in a transmissible IncI1 plasmid pNDM13-SR33. Sequence analysis of bla NDM-13-positive genomes downloaded from GenBank revealed that a genetic context (ΔISAba125-bla NDM-13-ble MBL-trpF) and a hybrid promoter (consisting of −35 sequences provided by ISAba125 and −10 sequences) were conserved. ISAba125 was truncated by IS1294 in three plasmids carrying bla NDM-13, including pNDM13-SR33. To our knowledge, this is the first report of bla NDM-13 carried by Salmonella. The emergence of bla NDM-13 in a clinical MDR S. Rissen ST469 strain highlights the critical need for monitoring and controlling the dissemination of bla NDM-13. bla NDM-13 carried by a transmissible IncI1 plasmid may result in an increased risk of bla NDM-13 transmission. IS1294 may be involved in the movement of bla NDM-13.
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影响因子：
16.6
作者：
Acman M;Wang R;van Dorp L;Shaw LP;Wang Q;Luhmann N;Yin Y;Sun S;Chen H;Wang H;Balloux F
通讯作者：
Balloux F
影响因子：
5.2
作者：
Garcia-Fernandez, Aurora;Chiaretto, Giuseppina;Carattoli, Alessandra
通讯作者：
Carattoli, Alessandra
影响因子：
5.6
作者：
Li X;Zhao D;Li W;Sun J;Zhang X
通讯作者：
Zhang X
影响因子：
10.7
作者：
Kumar, Sudhir;Stecher, Glen;Tamura, Koichiro
通讯作者：
Tamura, Koichiro
影响因子：
--
作者：
Dortet L;Poirel L;Nordmann P
通讯作者：
Nordmann P