Label-free and enzyme-free platform for the construction of advanced DNA logic devices based on the assembly of graphene oxide and DNA-templated AgNCs
Label-free and enzyme-free platform for the construction of advanced DNA logic devices based on the assembly of graphene oxide and DNA-templated AgNCs
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无标记、无酶平台，用于构建基于氧化石墨烯和 DNA 模板 AgNC 组装的先进 DNA 逻辑器件
DOI：
10.1039/c6nr00032k
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发表时间：
2016-02-14
期刊：
影响因子：
6.7
通讯作者：
Dong, Shaojun
中科院分区：
文献类型：
--
作者：
Fan, Daoqing;Zhu, Jinbo;Dong, Shaojun
基于DNA的分子逻辑计算在生物分析、疾病智能诊断等纳米技术领域引起了广泛的关注。本文以2比1和4比2编码器和1比2解码器为模型分子逻辑器件，首次将氧化石墨烯（GO）对DNA模板AgNC的猝灭能力与卟啉染料的G-quadruplex增强荧光强度相结合，构建了无标记无酶双输出的先进DNA分子逻辑器件。此外，通过将负逻辑转换应用于异或逻辑门并结合抑制逻辑门，我们还运行了无标记无酶比较器。
DNA-based molecular logic computation has drawn extensive attention in bioanalysis, intelligent diagnostics of diseases and other nanotechnology areas. Herein, taking 2-to-1 and 4-to-2 encoders and a 1-to-2 decoder as model molecular logic devices, we for the first time combined the quenching ability of GO (graphene oxide) to DNA-templated AgNCs with G-quadruplex-enhanced fluorescence intensity of porphyrin dyes for the construction of label-free and enzyme-free dual-output advanced DNA molecular logic devices. Also, through the application of negative logic conversion to an XOR logic gate and combined with an INHIBIT logic gate, we also operated a label-free and enzyme-free comparator.